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Cancers
Special Issues
Urological Cancer: Epidemiology, Prevention and Quality of Life
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Urological Cancer: Epidemiology, Prevention and Quality of Life

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 3158

Special Issue Editor

Dr. Xin Xu

E-Mail Website
Guest Editor
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Interests: urologic cancer; epidemiology

Special Issue Information

Dear Colleagues,

Cancer ranks as a leading cause of death and represents an important barrier to increasing life expectancy worldwide. Accordingly, urologic cancer burden has increased globally amid population growth and aging. High-income countries face the highest incidence and death rates; however, obesity-attributed kidney cancer deaths are increasing in developing countries. Efforts to expand the global oncologic workforce and reduce preventable factors may lessen cancer disparities in developing countries. This Special Issue of Cancers intends to shed some light on the complexity of this field and will consider all appropriate contributions from scientists and clinicians alike that aim to prevent urologic cancer and improve patients’ quality of life. This Special Issue will include epidemiological studies that aim to identify potential modifiable protective and risk factors in urologic cancer. This Special Issue will also look to include interventions and clinical trial results to improve the prevention and early detection of urologic cancer, which would potentially improve survival. We also welcome review articles, meta-analyses, and methodological tutorials that clearly contribute a new perspective.

I look forward to receiving your contributions.

Dr. Xin Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • urologic cancer
  • kidney cancer
  • bladder cancer
  • prostate cancer
  • epidemiology
  • prevention
  • risk factors

Published Papers (3 papers)

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Research

16 pages, 436 KiB  
Article
Perspectives and Concerns on Late Effects Regarding Sexuality among Adolescents and Young Adults Treated for Testicular Germ Cell Tumor: The PRICELESS-Study—A Qualitative Study
by Stefan T. Kuiper, Daniëlle Zweers, Britt B. M. Suelmann, Richard P. Meijer and Sigrid C. J. M. Vervoort
Cancers 2024, 16(4), 715; https://doi.org/10.3390/cancers16040715 - 08 Feb 2024
Viewed by 659
Abstract
This study aimed to explore perspectives and concerns regarding sexuality among adolescents and young adults (AYAs) possibly experiencing late effects after testicular germ cell tumor (TGCT) treatment. A qualitative study was performed in which semi-structured interviews were held with thirteen AYAs from a [...] Read more.
This study aimed to explore perspectives and concerns regarding sexuality among adolescents and young adults (AYAs) possibly experiencing late effects after testicular germ cell tumor (TGCT) treatment. A qualitative study was performed in which semi-structured interviews were held with thirteen AYAs from a center of expertise for TGCT in the Netherlands. Data were analyzed using Braun and Clark’s thematic analysis method. Seven interacting and interconnected themes were found: desire to have children, rediscovering sexuality, insecurity about sexual performance, acceptance of physical change, loss of masculinity, burden on relationship, and openness in discussing sexuality. Concerns about the desire to have children seem to play a significant role. In conclusion, TGCT patients face multiple changes (physical, emotional, relational, and sexual), followed by a difficult period of acceptance, after which a new phase of rediscovering sexuality appeared. These findings can help to make healthcare professionals aware of the underlying mechanisms and concerns about sexuality. Furthermore, insights can help to develop sexuality-themed items for a broader monitoring tool to structurally assess the late effects to support discussing sexuality. Full article
(This article belongs to the Special Issue Urological Cancer: Epidemiology, Prevention and Quality of Life)
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10 pages, 6893 KiB  
Article
The Prognostic Role of Body Mass Index on Oncological Outcomes of Upper Tract Urothelial Carcinoma
by Kang Liu, Hongda Zhao, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Pilar Laguna, Paolo Gontero, Iliya Saltirov and Jean de la Rosette
Cancers 2023, 15(22), 5364; https://doi.org/10.3390/cancers15225364 - 10 Nov 2023
Viewed by 747
Abstract
(1) Objective: The aim of this study was to evaluate whether overweight and obese upper urinary tract carcinoma (UTUC) patients have better or worse survival outcomes. (2) Methods: The Clinical Research Office of the Endourology Society Urothelial Carcinomas of the Upper Tract (CROES-UTUC) [...] Read more.
(1) Objective: The aim of this study was to evaluate whether overweight and obese upper urinary tract carcinoma (UTUC) patients have better or worse survival outcomes. (2) Methods: The Clinical Research Office of the Endourology Society Urothelial Carcinomas of the Upper Tract (CROES-UTUC) Registry was used to extract the data of normal-weight or overweight/obese UTUC patients between 2014 and 2019. Patients with a BMI between 18.5 and 24.9 kg/m2 were defined as normal weight, while those with a BMI ≥ 25.0 kg/m2 were considered as overweight/obese group. We compared baseline characteristics among groups categorized by different BMIs. The Kaplan–Meier plots with the log-rank test were used to explore the overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS). Propensity score matching was performed to eliminate the differences in clinicopathologic features. The Declaration of Helsinki was followed during this study. (3) Results: Of 1196 UTUC patients, 486 patients (40.6%) were normal weight, while 710 patients (59.4%) presented with a BMI ≥ 25.0 kg/m2. After propensity score matching, all baseline characteristics were balanced. For normal weight and overweight/obese patients, 2-year overall survival rates were 77.8% and 87.2%, 2-year cancer-specific survival rates were 85.2% and 92.7%, and 2-year recurrence rates were 50.6% and 73.0%, respectively. The overweight patients obtained a better RFS (p = 0.003, HR 0.548, 95% CI 0.368–0.916) while their OS (p = 0.373, HR 0.761, 95% CI 0.416–1.390) and CSS (p = 0.272, HR 0.640, 95% CI 0.287–1.427) were similar to normal weight patients. (4) Conclusions: Being overweight/obese (BMI ≥ 25.0 kg/m2) was associated with a decreased risk of recurrence in UTUC patients but not overall survival or cancer-specific survival. Full article
(This article belongs to the Special Issue Urological Cancer: Epidemiology, Prevention and Quality of Life)
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9 pages, 421 KiB  
Communication
Dietary Intake of Anthocyanidins and Renal Cancer Risk: A Prospective Study
by Xin Xu, Yi Zhu, Shiqi Li and Dan Xia
Cancers 2023, 15(5), 1406; https://doi.org/10.3390/cancers15051406 - 23 Feb 2023
Cited by 4 | Viewed by 1284
Abstract
Evidence on the association between anthocyanidin intake and renal cancer risk is limited. The aim of this study was to assess the association of anthocyanidin intake with renal cancer risk in the large prospective Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. [...] Read more.
Evidence on the association between anthocyanidin intake and renal cancer risk is limited. The aim of this study was to assess the association of anthocyanidin intake with renal cancer risk in the large prospective Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. The cohort for this analysis consisted of 101,156 participants. A Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and the 95% confidence intervals (CIs). A restricted cubic spline model with three knots (i.e., 10th, 50th, and 90th percentiles) was used to model a smooth curve. A total of 409 renal cancer cases were identified over a median follow-up of 12.2 years. In the categorical analysis with a fully adjusted model, a higher dietary anthocyanidin consumption was associated with a lower risk of renal cancer (HRQ4vsQ1: 0.68; 95% CI: 0.51–0.92; p for trend < 0.010). A similar pattern was obtained when anthocyanidin intake was analyzed as a continuous variable. The HR of one-SD increment in the anthocyanidin intake for renal cancer risk was 0.88 (95% CI: 0.77–1.00, p = 0.043). The restricted cubic spline model revealed a reduced risk of renal cancer with a higher intake of anthocyanidins and there was no statistical evidence for nonlinearity (p for nonlinearity = 0.207). In conclusion, in this large American population, a higher dietary anthocyanidin consumption was associated with a lower risk of renal cancer. Future cohort studies are warranted to verify our preliminary findings and to explore the underlying mechanisms in this regard. Full article
(This article belongs to the Special Issue Urological Cancer: Epidemiology, Prevention and Quality of Life)
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