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Cancers
Special Issues
Gastrointestinal Cancers: Advances in Diagnostic, Prognostic, and Therapeutics
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Gastrointestinal Cancers: Advances in Diagnostic, Prognostic, and Therapeutics

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2483

Special Issue Editors

Dr. Mauro Giuffrè

E-Mail Website
Guest Editor
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
Interests: liver cirrhosis; HCC; portal hypertension; esophageal varices; liver elastography; spleen elastography
Special Issues, Collections and Topics in MDPI journals
Dr. Caecilia Sukowati

E-Mail Website
Guest Editor
1. Fondazione Italiana Fegato ONLUS, Trieste, Italy
2. Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Jakarta, Indonesia
Interests: hepatocellular carcinoma; immunotherapy; stem cells; cancer stem cells

Special Issue Information

Dear Colleagues,

Gastrointestinal cancers comprise a wide array of tumors interesting the whole gastrointestinal tract. As reported by the World Health Organization, approximately 3.5 million new gastrointestinal cancer cases were diagnosed worldwide in 2018. Notably, colorectal cancer and gastric cancer are the third and fifth most frequent types of cancer, respectively and are amongst the fifth most common causes of cancer-related death worldwide. Despite the advancement that increased early diagnostic rates and more efficient treatment strategies, these types of cancers are burdened by high mortality rates.

We are pleased to invite you to submit your manuscripts related to the aim of this special issue, which is to report the current advancements in diagnostic and therapeutic strategies and better prognostic stratification for gastrointestinal cancers.

In this Special Issue, basic and clinical studies for original research articles and reviews, are welcome. Research areas may include (but are not limited to) the following:

  • Esophageal, gastric, and duodenal cancers;
  • Biliary and pancreatic cancers;
  • Hepatocellular Carcinoma;
  • Neuroendocrine tumors;
  • Colorectal cancers.

We look forward to receiving your contributions.

Dr. Mauro Giuffrè
Dr. Caecilia Sukowati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophageal cancer
  • gastric cancer
  • pancreatic cancer
  • biliary neoplastic disease
  • neuroendocrine tumors
  • NET
  • colorectal cancer
  • hepatocellular carcinoma
  • screening
  • surgery
  • radiology
  • histology

Published Papers (2 papers)

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Research

25 pages, 8008 KiB  
Article
Integrated Network Analysis of microRNAs, mRNAs, and Proteins Reveals the Regulatory Interaction between hsa-mir-200b and CFL2 Associated with Advanced Stage and Poor Prognosis in Patients with Intestinal Gastric Cancer
by Everton Cruz dos Santos, Paulo Rohan, Renata Binato and Eliana Abdelhay
Cancers 2023, 15(22), 5374; https://doi.org/10.3390/cancers15225374 - 12 Nov 2023
Viewed by 964
Abstract
Intestinal gastric cancer (IGC) carcinogenesis results from a complex interplay between environmental and molecular factors, ultimately contributing to disease development. We used integrative bioinformatic analysis to investigate IGC high-throughput molecular data to uncover interactions among differentially expressed genes, microRNAs, and proteins and their [...] Read more.
Intestinal gastric cancer (IGC) carcinogenesis results from a complex interplay between environmental and molecular factors, ultimately contributing to disease development. We used integrative bioinformatic analysis to investigate IGC high-throughput molecular data to uncover interactions among differentially expressed genes, microRNAs, and proteins and their roles in IGC. An integrated network was generated based on experimentally validated microRNA-gene/protein interaction data, with three regulatory circuits involved in a complex network contributing to IGC progression. Key regulators were determined, including 23 microRNA and 15 gene/protein hubs. The regulatory circuit networks were associated with hallmarks of cancer, e.g., cell death, apoptosis and the cell cycle, the immune response, and epithelial-to-mesenchymal transition, indicating that different mechanisms of gene regulation impact similar biological functions. Altered expression of hubs was related to the clinicopathological characteristics of IGC patients and showed good performance in discriminating tumors from adjacent nontumor tissues and in relation to T stage and overall survival (OS). Interestingly, expression of upregulated hub hsa-mir-200b and its downregulated target hub gene/protein CFL2 were related not only to pathological T staging and OS but also to changes during IGC carcinogenesis. Our study suggests that regulation of CFL2 by hsa-miR-200b is a dynamic process during tumor progression and that this control plays essential roles in IGC development. Overall, the results indicate that this regulatory interaction is an important component in IGC pathogenesis. Also, we identified a novel molecular interplay between microRNAs, proteins, and genes associated with IGC in a complex biological network and the hubs closely related to IGC carcinogenesis as potential biomarkers. Full article
(This article belongs to the Special Issue Gastrointestinal Cancers: Advances in Diagnostic, Prognostic, and Therapeutics)
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15 pages, 850 KiB  
Article
Impact of Age at Diagnosis on Clinicopathological Features, Prognosis, and Management of Gastric Cancer: A Retrospective Single-Center Experience from Spain
by Cristina Díaz del Arco, Luis Ortega Medina, Lourdes Estrada Muñoz, Elena Molina Roldán, Soledad García Gómez de las Heras and María Jesús Fernández Aceñero
Cancers 2023, 15(17), 4241; https://doi.org/10.3390/cancers15174241 - 24 Aug 2023
Viewed by 943
Abstract
The impact of age on various aspects of gastric cancer (GC) remains controversial. Clarifying this issue can improve our understanding of the disease, refine risk stratification models, and aid in personalized therapeutic approaches. This study aimed to evaluate the influence of age at [...] Read more.
The impact of age on various aspects of gastric cancer (GC) remains controversial. Clarifying this issue can improve our understanding of the disease, refine risk stratification models, and aid in personalized therapeutic approaches. This study aimed to evaluate the influence of age at diagnosis on the clinicopathological features, prognosis, and management of a specific cohort of Spanish patients with resected GC. The study encompassed 315 patients treated at a single tertiary hospital in Spain, divided into two age-based subgroups: ≤65 years and >65 years. The mean and median ages at diagnosis were 72 and 76 years. Most tumors were diagnosed at pT3 stage (49.2%), and 59.6% of patients had lymph node metastases. 21.3% of cases were diagnosed with GC at age ≤ 65 years. Younger patients showed a significantly higher prevalence of flat, diffuse, high-grade tumors, signet-ring cells, perineural infiltration, D2 lymphadenectomies, and adjuvant therapy. They also exhibited a higher rate of recurrences, but had a significantly longer follow-up. Kaplan-Meier curves indicated no significant prognostic differences based on age. Finally, age did not independently predict overall survival or disease-free survival. Our results suggest that younger patients may require more aggressive treatment due to adverse clinicopathologic features, but the lack of prognostic differences among age groups in our cohort indicates the need for further investigation into the complex interplay between age, clinicopathologic factors, and long-term outcomes in GC. Full article
(This article belongs to the Special Issue Gastrointestinal Cancers: Advances in Diagnostic, Prognostic, and Therapeutics)
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