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Cancers
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Head and Neck Cancer: Epidemiology, Prevention, Treatment, and Quality of...
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Head and Neck Cancer: Epidemiology, Prevention, Treatment, and Quality of Life

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 4545

Special Issue Editor

Dr. Melissa Henry

E-Mail Website
Guest Editor
1. Department of Oncology, Faculty of Medicine, McGill University, Montreal, QC H3A 0G4, Canada
2. Lady-Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada
Interests: oncology; cancer; quality of life; advanced cancer; head and neck cancer; sociobehavioural determinants of health; prevention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancers of the head and neck are the seventh most common cancers worldwide, with over 600,000 new cases annually. They represent different cancer sites including the oral cavity (lips, buccal mucosa, anterior tongue, hard palate, floor of mouth and retromolar trigone), nasopharynx, oropharynx (tonsils, base of tongue, soft palate, uvula, and posterior pharyngeal wall), hypopharynx, and larynx. Head and neck cancers are etiologically linked to the human papilloma virus (HPV) for oropharyngeal cancer and to health behaviors such as smoking and alcohol for non-HPV squamous cell carcinomas; the latter is known to be patterned with social disparities. Head and neck cancers carry an important burden of disease and treatments, with rehabilitation a mainstay as patients often experience disfigurement and dysfunction (e.g., eating, speech, breathing, mobility, distress). Treatments comprise a combination of surgery, radiation therapy, chemotherapy, and/or targeted therapies, with an attention to preserving function and quality of life. This Special Issue is designed to feature research on the epidemiology, prevention, treatment, and quality of life of head and neck cancers. We invite authors to contribute to this issue, which will allow more visibility to a population that is often under-served and -researched.

You may choose our Joint Special Issue in Current Oncology.

Dr. Melissa Henry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • epidemiology
  • prevention
  • treatment
  • quality of life

Published Papers (3 papers)

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12 pages, 879 KiB  
Article
Predictive Factors for Critical Weight Loss in Saudi Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy
by Alaa S. Redwan, Fayrooz A. Kattan, Maha A. Alidrisi, Gayur A. Ali, Mazen M. Ghaith, Ahmad F. Arbaeen, Hussain A. Almasmoum, Najlaa H. Almohmadi, Sarah O. Alkholy, Walaa E. Alhassani, Wafaa F. Abusudah, Abrar M. Babateen, Mai A. Ghabashi, Ahmad A. Obeidat, Azzam N. Al Yacoub, Awfa Y. Alazzeh and Firas S. Azzeh
Cancers 2024, 16(2), 414; https://doi.org/10.3390/cancers16020414 - 18 Jan 2024
Viewed by 907
Abstract
Weight loss is a significant health problem among patients with head and neck cancer (HNC) that is attributable primarily to the tumor or tumor therapy. Critical weight loss (CWL) is defined as the unintentional loss of ≥5% of weight. Therefore, this study’s goal [...] Read more.
Weight loss is a significant health problem among patients with head and neck cancer (HNC) that is attributable primarily to the tumor or tumor therapy. Critical weight loss (CWL) is defined as the unintentional loss of ≥5% of weight. Therefore, this study’s goal was to investigate and determine the possible factors influencing CWL among patients with HNC who have received radiotherapy or concurrent chemoradiotherapy (CCRT). We conducted a retrospective analysis of 175 patients who received radiotherapy or CCRT as either their primary, adjuvant, or combined treatment at the Oncology Center in King Abdullah Medical City. All patients were ≥18 years of age and diagnosed with HNC with no metastasis. The study results showed that 107 patients (61%) had CWL, while 68 (39%) did not. The following factors were significantly predictive of CWL with a multivariate regression analysis: pretreatment BMI (AOR = 1.1, 95% CI = 1.02–1.17), oral cavity cancer (AOR = 10.36, 95% CI = 1.13–94.55), and male sex (AOR = 3.15, 95% CI = 1.39–7.11). In conclusion, weight loss is highly prevalent among HNC patients during treatment. Accordingly, pretreatment BMI, cancer in the oral cavity, and being male can be considered predictive factors for CWL. Full article
(This article belongs to the Special Issue Head and Neck Cancer: Epidemiology, Prevention, Treatment, and Quality of Life)
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13 pages, 1423 KiB  
Article
Quality of Life for Head and Neck Cancer Patients: A 10-Year Bibliographic Analysis
by Siti Nur Akmal Ghazali, Caryn Mei Hsien Chan, Marfu’ah Nik Eezamuddeen, Hanani Abdul Manan and Noorazrul Yahya
Cancers 2023, 15(18), 4551; https://doi.org/10.3390/cancers15184551 - 14 Sep 2023
Cited by 1 | Viewed by 1022
Abstract
Head and neck cancers (HNCs) have a profound impact on patients, affecting not only their physical appearance but also fundamental aspects of their daily lives. This bibliometric study examines the landscape of scientific research pertaining to the quality of life (QoL) among head [...] Read more.
Head and neck cancers (HNCs) have a profound impact on patients, affecting not only their physical appearance but also fundamental aspects of their daily lives. This bibliometric study examines the landscape of scientific research pertaining to the quality of life (QoL) among head and neck cancer (HNC) patients. By employing data and bibliometric analysis derived from the Web of Science Core Collection (WOS-CC) and employing R-package and VOSviewer for visualization, the study assesses the current status of and prominent areas of focus within the literature over the past decade. The analysis reveals noteworthy countries, journals, and institutions that have exhibited notable productivity in this research domain between 2013 and 2022. Notably, the United States, the Supportive Care in Cancer journal, and the University of Pittsburgh emerged as the leading contributors. Moreover, there was a discernible shift, with an increasing focus on the significance of QoL within the survivorship context, exemplified by the emergence and subsequent peak of related keywords in 2020 and the subsequent year, respectively. The temporal analysis additionally reveals a transition towards specific QoL indices, such as dysphagia and oral mucositis. Therefore, the increasing relevance of survivorship further underscores the need for studies that address the associated concerns and challenges faced by patients. Full article
(This article belongs to the Special Issue Head and Neck Cancer: Epidemiology, Prevention, Treatment, and Quality of Life)
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0 pages, 600 KiB  
Systematic Review
Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide
by Lady Paola Aristizabal Arboleda, Genival Barbosa de Carvalho, Alan Roger Santos-Silva, Gisele Aparecida Fernandes, Jose Guilherme Vartanian, David I. Conway, Shama Virani, Paul Brennan, Luiz Paulo Kowalski and Maria Paula Curado
Cancers 2023, 15(17), 4405; https://doi.org/10.3390/cancers15174405 - 03 Sep 2023
Cited by 5 | Viewed by 1929
Abstract
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, [...] Read more.
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for inclusion using EndNote-20 and Rayyan online software. No language or publication date restrictions were applied. The results were analyzed descriptively considering the most updated CPG version. In total, 25 CPGs covering the head and neck region (10), the larynx (7), the oral cavity (5), and the oropharynx (3), were found in 13 geographical regions, and 19 were developed by medical societies from 1996 to 2023. Surgery and RT remain the main modalities for early-stage HNC, with surgery preferred in low-resource countries, and RT in selected cases, especially in the larynx/oropharynx aiming to achieve a cure with organ preservation. Human papillomavirus infection for oropharyngeal SCC is not tested in some Asian countries and there is still no consensus to treat p16-positive cases differently from p16-negative. Recommendations for larynx preservation vary according to facilities in each country, however, individualized choice is emphasized. Inequality across countries/continents is evident, with a similar pattern of recommendations among developed as well as developing ones. No CPGs were found in Latin America as well as Oceania countries, where the incidence of HNC is high and limitations of access to treatment may be encountered. Full article
(This article belongs to the Special Issue Head and Neck Cancer: Epidemiology, Prevention, Treatment, and Quality of Life)
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