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Journals
Biomolecules
Special Issues
Advances in Metabolites Produced by Microbiota
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Advances in Metabolites Produced by Microbiota

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2163

Special Issue Editor

Dr. Arancha Llama-Palacios

E-Mail Website
Guest Editor
Department of Medicine, Faculty of Medicine, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
Interests: microbiology; biochemistry; molecular biology; proteomics; biofilm bacteria

Special Issue Information

Dear Colleagues,

The term microbiota represents microorganisms (bacteria, fungi, archaea, viruses and parasites) that live in the body and interact with our cells. The meaning of the word microbiome is much broader and refers to the entire ecosystem, including microbial communities, their genes and metabolites, as well as the environmental and host conditions.

One of the main functions of the microbiota is metabolic, that is, the production of different metabolites from various substrates in the body. Among these metabolites produced by the microbiota, there are short-chain fatty acids, vitamins, bile acids, lipids and amino acids. These metabolites perform various regulatory functions to mediate the symbiotic relationships between microbes and their hosts.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Metabolites produced by microbiota (short-chain fatty acids, vitamins, bile acids, lipids and amino acids);
  • Metabolomics disorders;
  • Interaction between metabolites and the host.

 I look forward to receiving your contributions.

Dr. Arancha Llama-Palacios
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • metabolites
  • short-chain fatty acids
  • amino acids
  • vitamins

Published Papers (2 papers)

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Research

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11 pages, 993 KiB  
Article
Microbiota Metabolite Profiles and Dietary Intake in Older Individuals with Insomnia of Short vs. Normal Sleep Duration
by Carmel Even, Faiga Magzal, Tamar Shochat, Iris Haimov, Maayan Agmon and Snait Tamir
Biomolecules 2024, 14(4), 419; https://doi.org/10.3390/biom14040419 - 30 Mar 2024
Viewed by 807
Abstract
Recent evidence suggests that the gut microbiota plays a role in insomnia pathogenesis. This study compared the dietary habits and microbiota metabolites of older adults with insomnia of short vs. normal sleep duration (ISSD and INSD, respectively). Data collection included sleep assessment through [...] Read more.
Recent evidence suggests that the gut microbiota plays a role in insomnia pathogenesis. This study compared the dietary habits and microbiota metabolites of older adults with insomnia of short vs. normal sleep duration (ISSD and INSD, respectively). Data collection included sleep assessment through actigraphy, dietary analysis using the Food Frequency Questionnaire, and metabolomic profiling of stool samples. The results show that ISSD individuals had higher body mass index and a greater prevalence of hypertension. Significant dietary differences were observed, with the normal sleep group consuming more kilocalories per day and specific aromatic amino acids (AAAs) phenylalanine and tyrosine and branch-chain amino acid (BCAA) valine per protein content than the short sleep group. Moreover, metabolomic analysis identified elevated levels of the eight microbiota metabolites, benzophenone, pyrogallol, 5-aminopental, butyl acrylate, kojic acid, deoxycholic acid (DCA), trans-anethole, and 5-carboxyvanillic acid, in the short compared to the normal sleep group. The study contributes to the understanding of the potential role of dietary and microbial factors in insomnia, particularly in the context of sleep duration, and opens avenues for targeted dietary interventions and gut microbiota modulation as potential therapeutic approaches for treating insomnia. Full article
(This article belongs to the Special Issue Advances in Metabolites Produced by Microbiota)
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Review

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27 pages, 1532 KiB  
Review
Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
by Anna Maria Witkowska and Joe-Elie Salem
Biomolecules 2023, 13(9), 1340; https://doi.org/10.3390/biom13091340 - 02 Sep 2023
Viewed by 928
Abstract
Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating [...] Read more.
Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research. Full article
(This article belongs to the Special Issue Advances in Metabolites Produced by Microbiota)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The role of bacterial metabolites in Chronic obstructive pulmonary disease (COPD)
Authors: Yukuang Guo; et al
Affiliation: Global DMPK department in Takeda,

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