Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

Dear Colleagues,

There is compelling evidence to indicate the existence of shared clinical and pathological features between different neurodegenerative disorders, the most representative being the loss of redox balance and increased oxidative stress, abnormal protein aggregation, proteasomal and/or autophagic dysfunction, inflammation, neuronal apoptosis, and mitochondrial dysfunction. Increased oxidative stress, protein aggregation, and the failure of protein degradation pathways are intimately linked factors leading to altered protein homeostasis (proteostasis). Proteostasis is essential for cell health and viability and is ensured by the coordinated regulation of protein translation, folding, trafficking, and degradation. When the equilibrium among these mechanisms is lost, aberrant proteostasis occurs, representing a central molecular hallmark of aging and neurodegeneration. Brain cells hold a broad array of responses to cope with stress conditions, including endogenous antioxidant responses, protein quality control systems, and protein degradation pathways. The above-mentioned defensive mechanisms are linked to each other and share common molecular processes; therefore, their induction, as well as their dysfunction, is frequently reciprocal.

This Special Issue, entitled “Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders”, aim to explore the latest cutting-edge and novel developments and findings in this fundamental field of research by focusing on data collected in humans and in murine models of neurodegenerative diseases. We are also eager to publish research on innovative therapeutic strategies aiming to rescue stress responses and brain proteome alterations. Suggested themes to be covered include the role of redox balance and proteostasis regulation in neurodegenerative disorders, the molecular peculiarities behind the alteration of those mechanisms, the common traits among different neurodegenerative disorders, and interventional approaches to ameliorating brain damage.

For this thematic collection, we cordially invite investigators to contribute high-quality original research and review articles that cover any relevant topic in the study of redox and protein homeostasis in neurodegenerative disorders.

I look forward to receiving your contributions.

Prof. Dr. Fabio Di Domenico
Dr. Antonella Tramutola
Guest Editors

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• redox homeostasis
• oxidative stress
• antioxidant response
• proteostasis
• protein folding
• protein oxidation
• unfolded protein response
• ubiquitin proteosome system
• autophagy
• neurodegeneration