Crosstalk between Cell Redox Homeostasis and Synaptic Functions in Physiological and Pathological Conditions
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2087
Special Issue Editors
Interests: insulin signaling; insulin resistance; aging; Alzheimer’s disease; Down syndrome; neurodegeneration; mitochondrial bioenergetics
Special Issues, Collections and Topics in MDPI journals
Interests: brain; neuroscience; neurons; memory; neural plasticity; neurodegeneration; synaptic plasticity; synaptic transmission; synapses; Alzheimer's disease; neurobiology; neurodegenerative diseases; brain physiology; cellular neurophysiology; plasticity and metaplasticity; amyloid β-protein
Interests: neurodegeneration; neuroscience; oxidative stress; autophagy; Down syndrome; Alzheimer disease; brain metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The brain is a metabolically active organ with a high oxygen consumption rate and a consistent production of reactive oxygen and nitrogen species (ROS/RNS). Under physiological conditions, redox homeostasis is essential for the maintenance of key neuronal processes. The large amounts of ROS/RNS produced in the brain are lowered by an efficient network of antioxidants, but, sometimes, these protective systems fail, resulting in neuronal oxidative stress. Thus, redox imbalance plays a significant role in the progression of several neurodegenerative diseases. Intriguingly, ROS/RNS at low intracellular concentrations are involved in functional and structural changes at the base of the synaptic plasticity mechanisms, thus contributing to memory and learning functions. ROS/RNS can modulate long-term potentiation (LTP) and long-term depression (LTD), which are the cellular substrates for learning and memory. On the contrary, they can become detrimental to synaptic functions when they accumulate excessively in the brain. The thin line of role reversal from the positive to negative effects of these very highly reactive mediators is far from being fully understood.
In this Special Issue, we invite investigators to contribute original research, perspectives, or review articles that describe the relationship between cell redox homeostasis and synaptic functions in physiological and pathological conditions. We welcome submissions to further advance our understanding of the dual role of ROS/RNS in synaptic function and dysfunction, paving the way for development of new therapeutic approaches to neurological conditions associated with ROS/RNS.
Dr. Eugenio Barone
Dr. Cristian Ripoli
Dr. Antonella Tramutola
Guest Editors
Manuscript Submission Information
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