Role of Neuron-Glia and Glia-Glia Communications in the Brain Function: Recent Advances in the Central Nervous System Cellular Crosstalk and Signaling

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1806

Special Issue Editor


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Guest Editor
Institute of Neuroanatomy, Uniklinik RWTH Aachen, Aachen, Germany
Interests: neurodegeneration; neuroinflammation; neuropharmacology; neuropsychology; neural stem cells
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the Special Issue entitled “Role of Neuron-Glia and Glia-Glia Communications in the Brain Function: Recent Advances in the Central Nervous System Cellular Crosstalk and Signaling”.

The roles of glia in the brain include maintaining the ionic milieu of neurons, controlling the rate of propagation of nerve signals, controlling the uptake of neurotransmitters, modulating synaptic action, supplying some aspects of neuronal development, and participating in brain recovery from pathological damage. In addition to their role in brain homeostasis and neuroplasticity, glial cells play an essential role in modulating the brain's response to external and internal stresses. Therefore, they may also play an important role in brain function and the pathobiology of neurological disorders. However, the detailed role of glia-glia and neuron-glia interactions is only beginning to be understood and is the subject of this Special Issue.

This Special Issue aims to explore the role of communications between oligodendrocytes, microglia, astrocytes, and ependymal cells together and with neuronal cells in the pathobiology of wide-ranging central nervous system disorders. The manuscripts included in this issue will help to inspire new thinking about the similarities and differences between these signaling and communications in normal and pathologic conditions and lend insight into ways that these interactions could be targeted therapeutically. We seek to publish novel research and reflect the most recent advances on the latest contributions in the above areas, covering new signaling pathways and therapeutic approaches, as well as innovative review articles. This Special Issue should be of benefit to researchers worldwide, wherever there is a need to overcome challenges and strive for novel drug breakthroughs towards a new era of cell–cell communications in CNS disorders.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Brain tumors and brain cancer
  • Alzheimer disease
  • Parkinson disease
  • Huntington disease
  • Multiple sclerosis and Amyotrophic lateral sclerosis
  • Brain ischemia and spinal cord injury
  • Neuropsychiatric and Neurodevelopmental disorder
  • Other neuroinflammatory disorders

I look forward to receiving your contributions. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Dr. Nima Sanadgol
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glia-glia interactions
  • neuron-glia interactions
  • CNS cell–cell communication
  • neuroinflammation
  • neurodegeneration

Published Papers (1 paper)

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Research

16 pages, 3788 KiB  
Article
SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex
by Zrinko Baričević, Marta Pongrac, Matea Ivaničić, Helena Hreščak, Ivana Tomljanović, Antonela Petrović, Dan Cojoc, Miranda Mladinic and Jelena Ban
Biomolecules 2024, 14(1), 70; https://doi.org/10.3390/biom14010070 - 05 Jan 2024
Viewed by 1290
Abstract
(1) Background: Central nervous system (CNS) development is characterized by dynamic changes in cell proliferation and differentiation. Key regulators of these transitions are the transcription factors such as SOX2 and SOX9. SOX2 is involved in the maintenance of progenitor cell state and neural [...] Read more.
(1) Background: Central nervous system (CNS) development is characterized by dynamic changes in cell proliferation and differentiation. Key regulators of these transitions are the transcription factors such as SOX2 and SOX9. SOX2 is involved in the maintenance of progenitor cell state and neural stem cell multipotency, while SOX9, expressed in neurogenic niches, plays an important role in neuron/glia switch with predominant expression in astrocytes in the adult brain. (2) Methods: To validate SOX2 and SOX9 expression patterns in developing opossum (Monodelphis domestica) cortex, we used immunohistochemistry (IHC) and the isotropic fractionator method on fixed cortical tissue from comparable postnatal ages, as well as dissociated primary neuronal cultures. (3) Results: Neurons positive for both neuronal (TUJ1 or NeuN) and stem cell (SOX2) markers were identified, and their presence was confirmed with all methods and postnatal age groups (P4-6, P6-18, and P30) analyzed. SOX9 showed exclusive staining in non-neuronal cells, and it was coexpressed with SOX2. (4) Conclusions: The persistence of SOX2 expression in developing cortical neurons of M. domestica during the first postnatal month implies the functional role of SOX2 during neuronal differentiation and maturation, which was not previously reported in opossums. Full article
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