Role of Epigenetics in Organ Fibrosis
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 1537
Special Issue Editor
Interests: genetic and epigenetic regulatory mechanisms of organ fibrosis; AAV-based gene therapy; DNA methylation; non-coding RNA; CRISPR/Cas-based gene function analysis; single-cell multi-omics; spatial transcriptomics
Special Issue Information
Dear Colleagues,
Fibrosis is an intricate pathological process characterized by the gradual replacement of functional tissue with scar tissue, ultimately culminating in organ failure. This condition gives rise to a spectrum of distressing symptoms and, over time, poses a life-threatening risk to affected individuals.
Fibrosis is characterized by the excessive accumulation of the extracellular matrix (ECM), resulting in scarring and impaired organ function. Myofibroblasts are widely acknowledged as the principal drivers of ECM deposition and tissue remodeling. These specialized cells can originate from a range of sources, including resident fibroblasts, pericytes, endothelial cells, and more, in response to various internal and external stimuli. The transformation of these cells is largely influenced by epigenetic factors such as DNA methylation, histone modifications, and non-coding RNA. Consequently, a comprehensive understanding of these epigenetic mechanisms is essential for developing innovative therapeutic strategies with which to combat organ fibrosis.
This Special Issue aims to encompass a wide spectrum of topics related to epigenetics in organ fibrosis. We invite submissions of manuscripts that delve into various aspects, including the intricate cellular crosstalk between different cell types contributing to fibrosis, the impact of fibrosis on organ function, and the application of epigenetic interventions using animal models. We welcome both comprehensive review articles and original research contributions.
Dr. Xingbo Xu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic heart disease
- cardiac fibrosis
- heart failure
- fibroblast
- cardiomyocyte
- DNA methylation
- histone modification
- non-coding RNA
- gene therapy
