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Biomimetics
Special Issues
Biomaterials for Stem Cell Engineering
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Biomaterials for Stem Cell Engineering

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2252

Special Issue Editor

Dr. Michelle Griffin

E-Mail Website
Guest Editor
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
Interests: fibrosis; scarring; stem cells; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stem cells have the ability to both self-renew and differentiate into multiple cell types. They also respond to physical, chemical and biological cues in order to differentiate and proliferate. Engineering biomaterials that mimic and can control the chemical and biological signals that guide stem cell fat are of utmost importance. Such biomaterials are being applied to regenerate bone, cartilage, fat and muscle with significant advancements. The purpose of this Special Issue is to highlight the recent advances and development in stem cell tissue engineering to engineer all types of tissues and organs. The issue will discuss all types of biomaterials, including synthetic and natural. Biomaterials that guide stem cell fate through drug delivery or growth factor release are of high interest, and those that guide the regeneration of several organs, including cartilage, bone, tendon, skin, vascular tissue, liver, kidney and pancreas, will be highly considered.

Dr. Michelle Griffin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • biomaterials
  • tissue engineering
  • fibrosis
  • scarring

Published Papers (1 paper)

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Research

16 pages, 4580 KiB  
Article
A Bioinspired Astrocyte-Derived Coating Promotes the In Vitro Proliferation of Human Neural Stem Cells While Maintaining Their Stemness
by Andrea C. Jimenez-Vergara, Jacob Avina, Travis Jackson Block, Anne Sheldrake, Carson Koch, Anna Gonzalez, Jennifer Steele, Ana M. Díaz-Lasprilla and Dany J. Munoz-Pinto
Biomimetics 2023, 8(8), 589; https://doi.org/10.3390/biomimetics8080589 - 04 Dec 2023
Viewed by 1855
Abstract
The repair of neuronal tissue is a challenging process due to the limited proliferative capacity of neurons. Neural stem cells (NSCs) can aid in the regeneration process of neural tissue due to their high proliferation potential and capacity to differentiate into neurons. The [...] Read more.
The repair of neuronal tissue is a challenging process due to the limited proliferative capacity of neurons. Neural stem cells (NSCs) can aid in the regeneration process of neural tissue due to their high proliferation potential and capacity to differentiate into neurons. The therapeutic potential of these cells can only be achieved if sufficient cells are obtained without losing their differentiation potential. Toward this end, an astrocyte-derived coating (HAc) was evaluated as a promising substrate to promote the proliferation of NSCs. Mass spectroscopy and scanning electron microscopy were used to characterize the HAc. The proliferation rate and the expression of stemness and differentiation markers in NSCs cultured on the HAc were evaluated and compared to the responses of these cells to commonly used coating materials including Poly-L-Ornithine (PLO), and a Human Induced Pluripotent Stem Cell (HiPSC)-based coating. The use of the HAc promotes the in vitro cell growth of NSCs. The expression of the stemness markers Sox2 and Nestin, and the differentiation marker DCX in the HAc group was akin to the expression of these markers in the controls. In summary, HAc supported the proliferation of NSCs while maintaining their stemness and neural differentiation potential. Full article
(This article belongs to the Special Issue Biomaterials for Stem Cell Engineering)
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