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Biomimetics
Special Issues
Biomimetic Remineralization on Enamel and Dentin: 2nd Edition
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Biomimetic Remineralization on Enamel and Dentin: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 1676

Special Issue Editors

Dr. Hamid Nurrohman

E-Mail Website
Guest Editor
Department of Restorative Dentistry & Prosthodontics, School of Dentistry at Houston, University of Texas Health Science Center, Houston, TX, USA
Interests: cariology; biomimetic remineralization; biomimetic restorations; clinical translation
Dr. Jinhui Tao

E-Mail Website
Guest Editor
Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Interests: crystal nucleation and growth for calcium phosphates, calcium carbonates, metals, metal oxides, and metal-organic frameworks (MOFs) under different functional template substrates, additives, and electric fields by in situ AFM, TEM, and FTIR/Raman spectroscopy; development of advanced AFM capabilities such as 3D FFM, EC-AFM, scanning thermal microscopy, and magnetic force microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The philosophy of dental care toward prevention and minimally invasive restorative approaches by promoting remineralization is a critical element of dental treatments. Achieving oriented and ordered remineralization of demineralized dental enamel–dentin and restoring the sound tooth's good properties (mechanical, chemical, and morphological) are still challenges for dentists. With the progress in understanding the biomineralization of dental hard tissue, it will become possible to develop a biomimetic remineralization strategy by simulating the biomineralization process. A pure solution-based approach is not feasible for application in clinical dentistry. Therefore, research on the problem and progress associated with translating a scientifically sound concept into a clinically applicable approach is in order.

This 2nd Edition of the Special Issue aims to continue collecting contributions from different laboratories working on biomimetic remineralization and biomimetic restorations. Covering issues ranging from proof-of-concept to clinical translation, it provides an updated view of the potential strategies that would allow for the transfer of biomimetic remineralization and restoration methods into the dental clinic. The present collection of papers takes advantage of the open access format and is expected to provide a paradigm of the power of biomimetic approaches for discovering new and important research avenues and innovative solutions in nanotechnology and dentistry.

We believe this initiative will fill an essential gap in biomimetic remineralization, and the clinical delivery system will stimulate enthusiastic contributions from leading experts in the field. 

Dr. Hamid Nurrohman
Dr. Jinhui Tao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic remineralization
  • biomimetic restoration
  • enamel
  • dentin
  • clinical translation

Published Papers (2 papers)

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13 pages, 5063 KiB  
Article
Cytotoxicity, Differentiation, and Biocompatibility of Root-End Filling: A Comprehensive Study
by Ignacio Jimenez-Bueno, Rene Garcia-Contreras, Benjamin Aranda-Herrera, Hiroshi Sakagami, Christian Andrea Lopez-Ayuso, Hiroshi Nakajima, Carlos A. Jurado and Hamid Nurrohman
Biomimetics 2023, 8(7), 514; https://doi.org/10.3390/biomimetics8070514 - 29 Oct 2023
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Abstract
Assessing the biocompatibility of endodontic root-end filling materials through cell line responses is both essential and of utmost importance. This study aimed to the cytotoxicity of the type of cell death through apoptosis and autophagy, and odontoblast cell-like differentiation effects of MTA, zinc [...] Read more.
Assessing the biocompatibility of endodontic root-end filling materials through cell line responses is both essential and of utmost importance. This study aimed to the cytotoxicity of the type of cell death through apoptosis and autophagy, and odontoblast cell-like differentiation effects of MTA, zinc oxide–eugenol, and two experimental Portland cements modified with bismuth (Portland Bi) and barium (Portland Ba) on primary cell cultures. Material and methods: The cells corresponded to human periodontal ligament and gingival fibroblasts (HPLF, HGF), human pulp cells (HPC), and human squamous carcinoma cells from three different patients (HSC-2, -3, -4). The cements were inoculcated in different concentrations for cytotoxicity evaluation, DNA fragmentation in electrophoresis, apoptosis caspase activation, and autophagy antigen reaction, odontoblast-like cells were differentiated and tested for mineral deposition. The data were subject to a non-parametric test. Results: All cements caused a dose-dependent reduction in cell viability. Contact with zinc oxide–eugenol induced neither DNA fragmentation nor apoptotic caspase-3 activation and autophagy inhibitors (3-methyladenine, bafilomycin). Portland Bi accelerated significantly (p < 0.05) the differentiation of odontoblast-like cells. Within the limitation of this study, it was concluded that Portland cement with bismuth exhibits cytocompatibility and promotes odontoblast-like cell differentiation. This research contributes valuable insights into biocompatibility, suggesting its potential use in endodontic repair and biomimetic remineralization. Full article
(This article belongs to the Special Issue Biomimetic Remineralization on Enamel and Dentin: 2nd Edition)
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15 pages, 1867 KiB  
Systematic Review
Use of Nanoparticles in Regenerative Dentistry: A Systematic Review
by María Pilar Pecci-Lloret, Silvia Gea-Alcocer, Laura Murcia-Flores, Francisco Javier Rodríguez-Lozano and Ricardo Elías Oñate-Sánchez
Biomimetics 2024, 9(4), 243; https://doi.org/10.3390/biomimetics9040243 - 18 Apr 2024
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Abstract
Introduction: nanoparticles are tiny-sized materials whose characteristics and properties mean that their association with dental materials is being investigated to ascertain their effects and possible benefits on tooth structures. This systematic review aimed to qualitatively collect in vitro studies that address the potential [...] Read more.
Introduction: nanoparticles are tiny-sized materials whose characteristics and properties mean that their association with dental materials is being investigated to ascertain their effects and possible benefits on tooth structures. This systematic review aimed to qualitatively collect in vitro studies that address the potential application of different nanoparticles in dental regeneration. Following an exhaustive search and article selection process, 16 in vitro studies that met our eligibility criteria were included. BG-NPs were analyzed across five studies, with three demonstrating their impact on the growth and differentiation of human hDPSCs. CS-NPs were examined in three studies, with findings from two indicating a significant effect on the differentiation of SCAPs. Nanoparticles’ therapeutic potential and their stimulatory effect on promoting the regeneration of cells of the dentin-pulp complex have been proven. Their effect is altered according to the type of nanoparticle, concentration, and substances associated with them and, depending on these variables, they will affect the pulp, dentine, and dental cementum differently. Full article
(This article belongs to the Special Issue Biomimetic Remineralization on Enamel and Dentin: 2nd Edition)
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