Special Issue "Vision and the Immune System"
Deadline for manuscript submissions: 30 April 2024 | Viewed by 66
2. College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA
Interests: rhodopsin; retinitis pigmentosa; protein structure; dynamics; function and interactions; G protein coupled receptors; membrane proteins; pharmacology of non-model organisms; systems biology of pollutants; genotype to phenotype mapping
Vision is one of the most important senses, and the loss of vision has devastating consequences on one’s quality of life. Rhodopsin is the primary photoreceptor in mammalian dim-light vision, and mutations in rhodopsin have been associated with retinal degeneration. Over a decade ago, we predicted that rhodopsin interacts with chemokines based purely on the machine learning integration of large-omics datasets. At the time, the prediction seemed absurd, considering the established function of rhodopsin in vision and chemokines in the immune system. Since then, evidence has been mounting that vision and immune functions are interconnected systems within the human body in general, not just involving rhodopsin. On the one hand, the immune system safeguards the eyes from infections but also contributes to allergies, autoimmune disorders, and the degeneration of the retina in diseases such as diabetic retinopathy and retinitis pigmentosa. While the retina can attract immune cells, it also produces them. Understanding these systems’ relationships is essential for maintaining eye health and overall well-being. We would like to invite review and original contributions aimed at delineating these interconnections. Given the interdisciplinary nature of this topic, submitted papers may also be focused on areas of research and/or methodologies that may be applicable to address the topic, even if they have not yet been applied.
Prof. Dr. Judith Klein-Seetharaman
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- chemokine, cytokine and other immune-function-related proteins and non-coding RNAs in the retina
- retinal organoids
- rodent models
- fruit fly
- human patients
- database mining
- data-driven discovery of biological functions
- non-image-forming functions of opsin receptor proteins
- retinal degeneration
- Muller glia cells
- retinal pigment epithelium