Germ, Sertoli and Leydig Cells in the Testis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 254
Special Issue Editors
Interests: endocrinology; testis; puberty; development; spermatogenesis; testosterone; cell membrane; androgens
Interests: sertoli cells, testis, proliferation, cell metabolism; spermatogenesis; gametogenesis; cell biology; molecular biology
Special Issue Information
Dear Colleagues,
The testis are composed of seminiferous tubules, which contain germ cells that give rise to spermatozoa and somatic Sertoli cells, and interstitial tissue where steroid-producing Leydig cells live. The basic mechanisms regulating the differentiation and function of the reproductive axis have been studied for decades. However, many mechanisms underlying infertility in males still remain poorly known. The aim of this Special Issue is to address novel insights into the cellular and molecular processes of germs, and explore Sertoli and Leydig cell development and function, which may be impaired and cause male infertility. Special attention will be devoted to the spermatogonial stem cell niche and the distinct metabolic transitions from fetal life to adulthood, including the development of germ cells from pluripotent stem cells, as well as to the role of short and long non-coding RNAs in signalling pathways that may be involved in testicular cell development and function. Multiomic approaches, including single cell RNA sequencing analysis, lipidomic profiling and proteomics, will be addressed to help the understanding of the maturation process and function of these testis-specific cell populations. Finally, the deleterious effects of xenobiotics will be discussed, including the systematic and comprehensive evidence of the adverse effects on the male gonad.
Prof. Dr. Rodolfo Rey
Dr. María Fernanda Riera
Guest Editors
Manuscript Submission Information
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Keywords
- Sertoli cells
- Leydig cells
- spermatogonia
- spermatocytes
- spermatozoa
- stem cell niche
- testis
- omics analysis
- environmental toxicants
- non-coding RNAs
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Seminiferous epithelium cycle staging based on the development of the acrosome in rabbit testis
Authors: Avena, Virginia; Funes, Abi; Monclus, María; Saez, Tania; Fornes, Miguel
Affiliation: Argentina
Abstract: Seminiferous epithelium cycle staging in rabbit testis was described by classical histological stain, Hematoxylin - Eosin, or PAS stain. These techniques offer a limited possibility to classify spermatogenic cells compared with fluorescence detection of acrosome, or electron microscopy observations. In this paper, using different approaches, such as fluorescent dyes or ultrastructural details, we intend to offer new stages. Different environmental inputs, like a grease diet in rabbits, affect specific steps in sperm cell development that are also correlated with specific stages of epithelium. Correct definitions of stages could permit the study impact of different disruptors, by comparative analyses between normal and pathological epithelium stages, in the male reproduction system.
