Current Advances in Protein Homeostasis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 205
Special Issue Editors
Interests: non-canonical proteasome degradation pathway
Special Issue Information
Dear Colleagues,
Protein homeostasis, also known as proteostasis, refers to the fine-tuned balance between the production and degradation of cellular proteins. It is essential to cell function and survival. Key proteins involved in biological processes play convergent roles in cellular homeostasis, and their dysfunction promotes a variety of diseases including tumor development and neurodegeneration.
This Special issue aims to focus on deregulations that perturb ubiquitin-dependent or ubiquitin-independent proteasomal degradation of proteins, or aggregations of proteins associated with human disorders. Emerging evidence suggests that both ubiquitin-dependent and ubiquitin-independent proteasome pathways directly degrade sets of key proteins regulating cellular processes including cell growth and proliferation, apoptosis, DNA damage response, immune response, and metabolism. However, the mechanisms by which distinct proteasomal pathways specifically or synergistically elicit degradation functions are yet to be elucidated.
We are pleased to invite you to submit original research articles and reviews. Research areas may include (but not limited to) the following:
- cell biology;
- genetics;
- molecular biology;
- neuroscience.
We look forward to receiving your contributions.
Prof. Dr. Henry J. Li
Prof. Dr. Robb E. Moses
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein homeostasis
- proteostasis
- proteasomal degradation
- ubiquitin
- ubiquitin-independent
- neurodegeneration
