Animal Models of Leukemia
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 133
Special Issue Editor
Interests: acute myeloid leukemia; genetic mechanisms; molecular mechanisms; leukemia mouse model; immunosuppressive microenvironment; treatment strategies
Special Issue Information
Dear Colleagues,
Leukemia remains a significant challenge in the field of oncology. To better understand its complex mechanisms, progression, and potential therapeutic interventions, researchers have turned to animal models as invaluable tools. Animal models have emerged as indispensable tools not only for understanding leukemia's complexities but also for advancing drug discovery, deciphering mechanisms of adaptive resistance to therapy, and elucidating minimal residual disease (MRD). The advent of advanced genetic engineering techniques has paved the way for creating animal models with specific genetic alterations mirroring human leukemia-associated mutations. Xenograft models in particular stand as exemplars of translational research. By implanting human leukemia cells into immunodeficient animals, researchers can evaluate candidate drugs' efficacy, toxicity, and side effects in a context that closely mimics human physiology. Such models offer a crucial bridge between preclinical studies and clinical trials, accelerating the drug development pipeline. By observing how leukemia cells respond to treatment and evolve over time, researchers gain invaluable insights into the mechanisms driving adaptive resistance. As research continues to evolve, these models remain pivotal in providing new paths toward conquering leukemia and improving the lives of those affected by this complex disease. In this Special Issue, we welcome distinguished scholars in the field to share their efforts, concepts, and discoveries.
I look forward to receiving your contributions.
Dr. Rasoul Pourebrahim
Guest Editor
Manuscript Submission Information
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Keywords
- leukemia
- animal models
- immune microenvironment
- symptoms
- drug
- treatment
- white blood cells
- bone marrow and the lymphatic system
