Metabolic Regulation of Pancreatic Beta Cells

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue on “Metabolic Regulation of Pancreatic Beta Cells”. Pancreatic beta cells, nestled within the islets of Langerhans in the pancreas, play a critical role in maintaining glucose homeostasis by secreting insulin in response to changes in blood glucose levels. This finely tuned process is essential for orchestrating glucose uptake by tissues, storage of excess glucose as glycogen, and inhibition of hepatic glucose production. Dysfunction of these cells is a hallmark of diabetes mellitus, a complex metabolic disorder affecting millions worldwide. Understanding the intricate metabolic pathways and regulatory mechanisms governing pancreatic beta cell function is essential for developing novel therapeutic strategies to prevent and treat diabetes.

This Special Issue aims to delve into the intricate metabolic machinery that governs the function of pancreatic beta cells and explore its implications for diabetes research and therapy. By unraveling the molecular mechanisms underlying beta cell metabolism, we aim to uncover novel therapeutic targets and strategies to preserve or restore beta cell function in diabetes. This theme aligns closely with the scope of our journal, which serves as a platform for disseminating cutting-edge research in the fields of biochemistry, physiology, and developmental biology. We aspire to curate a comprehensive collection of articles that not only advance our understanding of beta cell biology but also pave the way for innovative approaches to diabetes management.

We welcome contributions spanning a wide spectrum of themes related to the metabolic regulation of pancreatic beta cells. Potential topics of interest include, but are not limited to, the molecular mechanisms underlying beta cell glucose sensing, insulin secretion pathways, mitochondrial metabolism, intracellular signaling cascades, and the impact of metabolic stressors on beta cell function and survival. We encourage submissions encompassing original research articles, reviews, perspectives, and methodological advancements that offer new insights into beta cell biology and its relevance to diabetes pathogenesis and therapy.

We eagerly anticipate your contributions and collaborative efforts in making this Special Issue a pivotal platform for research into the metabolic regulation of pancreatic beta cells.

Dr. Ishant Khurana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• pancreatic beta cells
• metabolism
• glucose homeostasis
• insulin secretion
• diabetes
• therapeutic targets
• beta cell development and function
• molecular mechanisms
• metabolic pathways
• diabetes therapy