Special Issue "Biological Bases of Alzheimer's Disease"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 10 December 2023 | Viewed by 145

Special Issue Editors

Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 171 64 Solna, Sweden
Interests: endocannabinoid system; Alzheimer’s; amyloid; inflammation; microglia; animal models; transmembrane proteins
Special Issues, Collections and Topics in MDPI journals
Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, 25123 Brescia, Italy
Interests: secondary metabolites; ethnopharmacology; abiotic stress; abiotic stress tolerance; cannabis sativa; cannabaceae; medical marijuana; phytocannabinoids; CB1 receptor; cannabidiol; tetrahydrocannabinol; CB2 receptor; cannabinoids; cannabinoid receptor agonists; cannabinoid receptor antagonists; cannabinoid receptor modulators
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia, characterized by impaired memory, cognition, and functionality in affected individuals. Its histological hallmarks consist of brain extracellular deposits of amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles of tau proteins. Although AD is a multifactorial disease, the main biological basis theory centers on the aberrant processing and accumulation of Aβ peptides, triggering neuronal damage and death. Genetic factors, such as mutations in APP, PSEN1, and PSEN2 genes, have been implicated in early onset familial AD, while polymorphisms in the APOE gene are a risk factor for late-onset AD. In addition to these molecular and genetic underpinnings, other biological factors such as oxidative stress, inflammation, and impaired brain metabolism play pivotal roles in disease progression. Despite the complexity of its etiology, recent advancements in neuroscience and molecular biology have provided promising routes for novel diagnostic markers and therapeutic strategies. Understanding the biological mechanisms of AD is critical to addressing the increasing number of people worldwide affected by this devastating disease.

This Special Issue welcomes submissions of original research articles, reviews, and short communications focusing on the biological mechanisms underlying the onset of AD to increase our understanding of its pathophysiology and contribute to the identification of new biological mechanisms that can be potentially targeted for its treatment.

Dr. Simone Tambaro
Prof. Dr. Andrea Mastinu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Alzheimer's disease
  • amyloid-beta (Aβ) plaques
  • neurofibrillary tangles
  • neuroinflammation
  • biological mechanisms
  • APP
  • PSEN
  • memory impairment

Published Papers

This special issue is now open for submission.
Back to TopTop