Physiology of Lymph Vessels: Structure, Function and Modelling (Volume II)
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 265
Special Issue Editor
Interests: lymphatic vessels physiology; lymph flow; lymph drainage; mechanisms of intrinsic lymphatic muscle contraction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is part of a series with, “Physiology of Lymph Vessels: Structure, Function, Modelling, and Clinical Perspectives”.
Lymphatic vessels provide a unique circulatory system that offers interstitial and serosal liquids a drainage route back into the blood stream. This task is particularly difficult as the vessels face a net pressure gradient that acts against the intended direction of the lymph from the periphery to the blood venous district. Furthermore, the hydraulic pressure of the tissue can be subatmosferic. Therefore, lymphatic vessels exploit two different pumping mechanisms, one that relies on external compression and/or distention forces exerted by the surrounding tissues, another that relies on the intrinsic, spontaneous contractile activity of the lymphatic musculature of the wall comprising lymphatic vessels. Parietal and intraluminal lymphatic valves cooperate with these two pumping mechanisms to attain lymph drainage and transport. Since the first discovery of lacteals by Aselli in 1622, work that was later published in 1627 after his death, the knowledge of lymphatic vessels’ physiology has lagged behind the wealth of data regarding blood circulation; this is despite lymphatics being a prominent actor in maintaining fluid volume homeostasis in tissues and serosal cavities. This Special Issue will highlight the most relevant and latest findings pertaining to lymphatic physiology, anatomy and histology, with a particular focus on new data coming from basic research, numerical modelling and comparative research among different species.
Dr. Andrea Moriondo
Guest Editor
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Keywords
- lymphatic vessel
- oedema
- lymphatic muscle
- spontaneous contractions
- functional imaging
- translational medicine
- intrinsic pumping
- extrinsic pumping
- fluid homeostasis
- numerical modelling
