DNA Repair & Damage Signalling Pathways in Mitosis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 165
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chromosomal aberrations occur in cells with a high frequency every day. They result from under-replicated DNA, unresolved recombination intermediates, intertwined chromosomes, or broken DNA. Although, it was long thought that tissues are severely damaged when cells enter mitosis with such alterations, recent research revealed several mitotic repair and signaling pathways. They are the focus of this Special Issue. Contributions are invited that address (i) DNA synthesis in early mitosis (MiDAS), (ii) microhomology-mediated end-joining (MMEJ), (iii) structure-specific nucleases, (iv) the BTR (BLM, TOP3A, RMI1/2) complex, (v) ultrafine anaphase bridges, (vi) kinases, (vii) DNA damage checkpoint proteins (viii) topoisomerases and helicases, (ix) Fanconi anemia (FA) proteins, and (x) epigenetic modifiers or any other relevant mechanism. The work may involve any model system, prokaryotic cells, plant or human cells, as well as structural or in silico approaches.
Dr. Thomas Caspari
Guest Editor
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Keywords
- mitosis
- DNA repair
- MIDAS
- MMEJ
- checkpoint
- kinase
- nuclease
- helicase
- Fanconi
- topoisomerase
- epigenetics
- RHINO
- polymerase
