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Bioengineering
Special Issues
State of the Art in Interdisciplinary Microfluidics
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State of the Art in Interdisciplinary Microfluidics

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2959

Special Issue Editor

Dr. Jack Merrin

E-Mail Website
Guest Editor
Nanofabrication Facility, Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
Interests: microfluidics for biological applications and physics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics is becoming increasingly useful in biological and medical applications, in recent times having allowed for do-it-yourself home assays for the detection of COVID-19. Microfluidics allows one to probe single molecules, single cells, cell motility, complex organisms such as C. elegans, zebrafish, complex systems such as in immunology, or other phenomena such as plant root growth kinetics. Microfluidics research often bridges gaps between physics, biology, chemistry, and engineering, with recent advances in 3D printing with platforms such as Nanoscribe or UpNano systems potentially allowing for even more possibilities in the fabrication of microfluidic devices in applications spanning disciplines.

This Special Issue provides a platform and an advanced academic forum for experts in the area of microfluidics to showcase and share their technical knowledge and interdisciplinary scientific results. We look forward to your contributions.

Dr. Jack Merrin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • 3D printing
  • microfabrication
  • bioengineering
  • interdisciplinary

Published Papers (1 paper)

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Research

17 pages, 3139 KiB  
Article
Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System
by Gabriele Specioso, David Bovard, Filippo Zanetti, Fabio Maranzano, Céline Merg, Antonin Sandoz, Bjoern Titz, Federico Dalcanale, Julia Hoeng, Kasper Renggli and Laura Suter-Dick
Bioengineering 2022, 9(10), 516; https://doi.org/10.3390/bioengineering9100516 - 30 Sep 2022
Cited by 3 | Viewed by 2645
Abstract
There is a lack of physiologically relevant in vitro human kidney models for disease modelling and detecting drug-induced effects given the limited choice of cells and difficulty implementing quasi-physiological culture conditions. We investigated the influence of fluid shear stress on primary human renal [...] Read more.
There is a lack of physiologically relevant in vitro human kidney models for disease modelling and detecting drug-induced effects given the limited choice of cells and difficulty implementing quasi-physiological culture conditions. We investigated the influence of fluid shear stress on primary human renal proximal tubule epithelial cells (RPTECs) cultured in the micro-physiological Vitrofluid device. This system houses cells seeded on semipermeable membranes and can be connected to a regulable pump that enables controlled, unidirectional flow. After 7 days in culture, RPTECs maintained physiological characteristics such as barrier integrity, protein uptake ability, and expression of specific transporters (e.g., aquaporin-1). Exposure to constant apical side flow did not cause cytotoxicity, cell detachment, or intracellular reactive oxygen species accumulation. However, unidirectional flow profoundly affected cell morphology and led to primary cilia lengthening and alignment in the flow direction. The dynamic conditions also reduced cell proliferation, altered plasma membrane leakiness, increased cytokine secretion, and repressed histone deacetylase 6 and kidney injury molecule 1 expression. Cells under flow also remained susceptible to colistin-induced toxicity. Collectively, the results suggest that dynamic culture conditions in the Vitrofluid system promote a more differentiated phenotype in primary human RPTECs and represent an improved in vitro kidney model. Full article
(This article belongs to the Special Issue State of the Art in Interdisciplinary Microfluidics)
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