10th Anniversary of Bioengineering: Biochemical Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biochemical Engineering".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1933

Special Issue Editor

Special Issue Information

Dear Colleagues,

Biochemical engineering is a multidisciplinary field that applies principles of biology, chemistry, and engineering to develop processes and products involving biological materials. It aims to address global challenges related to healthcare, environmental sustainability, energy production, and industrial innovation by harnessing the potential of biological systems and processes. Due to advancements in molecular biology, biotechnology, genomics, computational methods, data science, and digitalization, the scope of biochemical engineering continually expands.

As one of the first established section of the journal Bioengineering, "Biochemical Engineering" Section has been at the forefront of disseminating cutting-edge research and advancements in the field. To commemorate this milestone, we are setting up this Special Issue.

Topics of interest for this Special Issue include, but are not limited to, the following:

  1. Designing, developing, and optimizing processes that utilize biological systems to produce valuable products.
  2. Synthetic biology techniques for engineering organisms or biological components for specific functions, like creating novel enzymes or metabolic pathways.
  3. The production of biopharmaceuticals, such as vaccines, monoclonal antibodies, and recombinant proteins, by using genetically engineered cells or microorganisms in bioreactors.
  4. Enzyme engineering and its applications.
  5. Environmental biotechnology such as bioremediation, waste treatment, and bio-based approaches for resource recovery.
  6. The Research and development of renewable energy sources.
  7. Data science enablers for accelerating the product life cycle.
  8. The use of digital twins for prediction and optimization of bioprocesses.
  9. End-to-end solutions for achieving intesified bioprocesses and continuous biomanufacturing (CBM).

Prof. Dr. Christoph Herwig
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biochemical engineering
  • bioprocesses
  • synthetic biology
  • biopharmaceuticals
  • enzyme engineering
  • environmental biotechnology
  • bioremediation
  • waste treatment
  • renewable energy
  • continuous biomanufacturing

Published Papers (2 papers)

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Research

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19 pages, 1657 KiB  
Article
Biohydrogen Production from Waste Black Cumin (Nigella Sativa) Extract Liquid
by Nesrin Dursun and Hakki Gülşen
Bioengineering 2024, 11(3), 282; https://doi.org/10.3390/bioengineering11030282 - 16 Mar 2024
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Abstract
Hydrogen creates water during combustion. Therefore, it is expected to be the most promising environmentally friendly energy alternative in the coming years. This study used extract liquid obtained from the waste nigella sativa generated by the black cumin oil industry. The performance of [...] Read more.
Hydrogen creates water during combustion. Therefore, it is expected to be the most promising environmentally friendly energy alternative in the coming years. This study used extract liquid obtained from the waste nigella sativa generated by the black cumin oil industry. The performance of biological hydrogen manufacturing via dark fermentation was investigated in the fluidized bed reactor (FBR) and completely stirred tank reactor (CSTR) under the operation conditions of pH 5.0, 4.0, and 6.0 and a hydraulic retention time (HRT) of 36 and 24 h. The performance of hydrogen manufacturing was determined to be good under an organic loading ratio (OLR) of 6.66 g.nigella sativa extract/L and pH 4.0. According to these conditions, the maximum amount of hydrogen in CSTR and FBR was found to be 20.8 and 7.6 mL H2/day, respectively. The operating process of the reactors displayed that a reduction in HRT augmented biohydrogen manufacturing. The work that used mixed culture found that the dominant microbial population at pH 4.0 involved Hydrogenimonas thermophila, Sulfurospirillum carboxydovorans, Sulfurospirillum cavolei, Sulfurospirillum alkalitolerans, and Thiofractor thiocaminus. No research on waste black cumin extract was found in biohydrogen studies, and it was determined that this substrate source is applicable for biological hydrogen manufacturing. Full article
(This article belongs to the Special Issue 10th Anniversary of Bioengineering: Biochemical Engineering)
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Review

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17 pages, 679 KiB  
Review
Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation
by Vishal Kumar Singh, Ioscani Jiménez del Val, Jarka Glassey and Fatemeh Kavousi
Bioengineering 2024, 11(6), 546; https://doi.org/10.3390/bioengineering11060546 - 27 May 2024
Viewed by 667
Abstract
Large-scale bioprocesses are increasing globally to cater to the larger market demands for biological products. As fermenter volumes increase, the efficiency of mixing decreases, and environmental gradients become more pronounced compared to smaller scales. Consequently, the cells experience gradients in process parameters, which [...] Read more.
Large-scale bioprocesses are increasing globally to cater to the larger market demands for biological products. As fermenter volumes increase, the efficiency of mixing decreases, and environmental gradients become more pronounced compared to smaller scales. Consequently, the cells experience gradients in process parameters, which in turn affects the efficiency and profitability of the process. Computational fluid dynamics (CFD) simulations are being widely embraced for their ability to simulate bioprocess performance, facilitate bioprocess upscaling, downsizing, and process optimisation. Recently, CFD approaches have been integrated with dynamic Cell reaction kinetic (CRK) modelling to generate valuable information about the cellular response to fluctuating hydrodynamic parameters inside large production processes. Such coupled approaches have the potential to facilitate informed decision-making in intelligent biomanufacturing, aligning with the principles of “Industry 4.0” concerning digitalisation and automation. In this review, we discuss the benefits of utilising integrated CFD-CRK models and the different approaches to integrating CFD-based bioreactor hydrodynamic models with cellular kinetic models. We also highlight the suitability of different coupling approaches for bioprocess modelling in the purview of associated computational loads. Full article
(This article belongs to the Special Issue 10th Anniversary of Bioengineering: Biochemical Engineering)
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