Advanced Research in Osteoarthritis and Osteoarthrosis Management and Regenerative Strategies

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Cellular and Molecular Bioengineering".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1522

Special Issue Editors


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Guest Editor
Sbarro Health Research Organization (SHRO), Temple University, 1900 N 12th St., Philadelphia, PA 19122, USA
Interests: regenerative medicine; micrografting; biotechnology; biology; tissue engineering; cartilage; bioprocess

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Guest Editor
Mauriziano Hospital, 10126 Turin, Italy
Interests: orthopedics; foot surgery; Achilles tendon

Special Issue Information

Dear Colleagues,

Osteoarthritis (OA) is a degenerative disease that leads to the loss of cartilage. Although it is commonly referred to as a disease of the joint cartilage, it affects all joint tissues equally and its pathogenesis is not yet completely understood. On the other hand, osteoarthrosis is a disorder of synovial joints that results from the destruction of the cartilage and subchondral bone. Both of these pathological conditions lead to chronic pain and disability in affected patients, and as a result, they represent a considerable socioeconomic burden. Despite the currently available therapies and advances in research, unfulfilled medical needs persist for OA treatment.

This Special Issue, entitled “Recent Advances in Osteoarthritis and Osteoarthrosis Management and Regenerative Strategies”, will focus on original research papers, case reports and comprehensive reviews that address cutting-edge experimental methodologies for multiscale investigations about tissue engineering and regenerative approaches by bringing together contributions from worldwide experts on stem cell biology, tissue engineering-based approaches, cartilage surgery strategies, cellular and experimental therapies and bioprocess development. The topics of interest for this Special Issue include, but are not limited to, the following:

  1. Advanced experimental techniques for characterizing inflammatory pathways;
  2. Novel biomaterials for bone/cartilage regeneration/reconstruction;
  3. Growth, remodeling and repair in bone/cartilage tissues;
  4. Investigations about new regenerative approach not only stem cells-based;
  5. Molecular and cellular mechanisms involved in the cartilage destruction;
  6. Current and future directions for 3D bioprinting to develop osteochondral unit constructs.

Dr. Antonio Graziano
Dr. Marco Marcarelli
Guest Editors

Manuscript Submission Information

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Keywords

  • osteoarthritis
  • osteoarthrosis
  • tissue engineering
  • tissue regeneration
  • grafting
  • biomaterials
  • cartilage repair
  • inflammation
  • cytokines
  • joints degeneration

Published Papers (1 paper)

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Research

12 pages, 3907 KiB  
Article
Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
by Dimitrios Tsoukas, Ilie Muntean, Christos Simos and Ruben Sabido-Vera
Bioengineering 2023, 10(11), 1294; https://doi.org/10.3390/bioengineering10111294 - 08 Nov 2023
Viewed by 1087
Abstract
Autologous micrografting technology (AMT®) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT® procedure in patients with early stages of knee osteoarthritis. Briefly, the AMT® [...] Read more.
Autologous micrografting technology (AMT®) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT® procedure in patients with early stages of knee osteoarthritis. Briefly, the AMT® procedure involved extraction of auricular cartilage, disaggregation using the Rigeneracons® SRT in 4.0 mL of saline solution, and injection of the disaggregated micrografts into the external femorotibial compartment area of the affected knee. Ten patients (4 men, 6 women; age range: 37–84 years) were included in the study. In all patients, there was a steady improvement in knee instability, pain, swelling, mechanical locking, stair climbing, and squatting at 1- and 6-months post-procedure. Improvement in mobility was observed as early as 3 weeks post-procedure in 2 patients. Significant improvements were seen in mean scores of all five subscales of Knee Injury and Osteoarthritis Outcome Score (KOOS [KOOS symptoms, KOOS pain, KOOS ADL, KOOS sport and recreation, and KOOS quality-of-life]) between pre-procedure and 1- and 6-months post-procedure (all p ≤ 0.05). Autologous auricular cartilage micrografts obtained by AMT® procedure (using Rigenera® technology) is an effective and safe protocol in the treatment of early stage knee osteoarthritis. These encouraging findings need to be validated in a larger patient population and in a randomized clinical trial (RCT). Full article
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