Advancing Regenerative Interventions in Fibrosis
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 184
Special Issue Editors
2. Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
3. Division of Pulmonary and Critical Care, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
Interests: fibrosis; pulmonary; resolution; lung healing; extracellular matrix; regeneration
Special Issue Information
Dear Colleagues,
Fibrotic diseases pose a significant global health challenge, being responsible for over 40% of all deaths worldwide. Fibrosis comes as the result of a chronic mild inflammatory response guided by TGF-β overexpression, macrophage type II activation, fibrocyte infiltration, and the deposition of extracellular matrix, scar tissue, and consequent organ dysfunction. This process is considered mostly irreversible, due to the lack of available treatments able to reverse fibrosis. This collection of articles explores cutting-edge research and innovations in regenerative medicine aimed at combating fibrosis. From novel therapeutic approaches to the latest breakthroughs in tissue engineering, we delve into the forefront of regenerative interventions. Together, we strive to uncover new strategies and insights that may lead to transformative treatments for fibrosis, ultimately improving the lives of millions afflicted by these debilitating conditions. Topics of interest for this Special Issue include, but are not limited to:
- Innovative drug discovery, testing, and experimentation in vitro and in vivo;
- Advanced experimental techniques to characterize the biology of fibrotic tissue (single- or mixed-cell cultures, 3D models, and animal models);
- Extracellular matrix protein dynamics and remodeling;
- Studies involving the characterization of the biomechanical properties of fibrotic tissue;
- Advanced computational models of fibrosis deposition to understand the possible mechanisms of resolution;
- Novel stimulating techniques to modulate the fibrotic tissue;
- Verification, validation, and testing of novel biomarkers of fibrotic disease and their development as possible new therapeutical targets for fibrosis resolution.
Dr. Ruben M.L. Colunga Biancatelli
Dr. Joshua M. Sill
Guest Editors
Manuscript Submission Information
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Keywords
- fibrotic tissue
- extracellular matrix proteins
- molecular dynamics
- fibrosis models
- computational models
- biomarkers of disease
