Neural Stem Cells for Modeling Neurological Diseases

Dear Colleagues,

Neural stem cells (NSCs) hold immense potential for advancing our understanding and treatment of neurological diseases. Their ability to self-renew, differentiate into various neural cell types, and recapitulate disease-specific phenotypes makes invaluable tools for use in disease modeling. This multidisciplinary frontier involves utilizing NSCs obtained from diverse sources, including embryonic stem cells, induced pluripotent stem cells, and adult neural tissues, to replicate the complexity of neurological disorders in vitro. By manipulating NSCs, researchers can generate three-dimensional organoids or two-dimensional culture systems that mimic the characteristics of neurodegenerative diseases, neurodevelopmental disorders, and other conditions affecting the nervous system. These NSC-based models enable the investigation of disease mechanisms, drug screening, and the development of personalized therapies. Furthermore, NSCs can be genetically modified to express disease-specific mutations, providing a powerful platform for understanding the molecular and cellular basis of various neurological conditions. This Special Issue illuminates recent advancements in NSCs utilization to model neurological diseases, highlighting their potential to unravel disease pathogenesis and facilitate the development of new therapeutic strategies.

Dr. Martin Cheung
Dr. Huseyin Sumer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• neural stem cells
• neurological diseases
• disease modeling
• neurodegenerative disorders
• neurodevelopmental disorders
• in vitro models
• organoids
• drug screening
• personalized therapies
• disease mechanisms