Mechanobiology in Biomedical Engineering

Dear Colleagues,

Advances in mechanobiology research continue to shape our understanding of how physical forces and mechanical properties influence biological processes in living organisms. Mechanobiology has significant implications for various fields. For instance, researchers incorporate mechanical cues into scaffold design and culture environments that promote the growth and differentiation of cells to form functional tissues. Understanding how mechanical forces influence cancer progression, metastasis, and response to treatment can lead to the development of novel cancer therapies and diagnostics. In orthopedics, mechanobiology research on bone and articular cartilage is crucial for developing treatments for osteoporosis and osteoarthritis. The knowledge of how mechanical forces affect neuronal development, axon guidance, and neural regeneration is also valuable for understanding neurodegenerative diseases and developing neural implants and tissue engineering approaches for spinal cord injuries. Furthermore, mechanobiology has influenced drug discovery efforts by identifying mechanosensitive drug targets and developing screening assays that incorporate mechanical cues. Finally, understanding the mechanical properties and micromechanical environments of tissues and how they change under different conditions is a fundamental aspect of mechanobiology. In summary, mechanobiology has diverse applications across the fields of biology, medicine, and engineering. Its interdisciplinary approach allows researchers to gain insights into the complex interactions between mechanical forces and biological systems, leading to advancements in healthcare, tissue engineering, and our overall understanding of life processes. In this Special Issue, all original research articles and reviews in mechanobiology are welcome.

Dr. Chun-Yuh Huang
Dr. Zhipeng Meng
Guest Editors

Manuscript Submission Information

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• mechanobiology
• biomechanics
• stem cells
• tissue engineering
• cancer
• bone
• articular cartilage
• intervertebral disc
• chondrocytes
• tumor microenvironment
• organ fibrosis
• mechanotransduction