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Bioengineering
Special Issues
Recent Development in Spine Biomechanics
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Recent Development in Spine Biomechanics

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomechanics and Sports Medicine".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 2739

Special Issue Editors

Dr. Deniz Erbulut

E-Mail Website
Guest Editor
Herston Biofabrication Institute, Metro North Hospital and Health Service, Brisbane, QLD 4029, Australia
Interests: FE modeling and analysis; spinal implant design; injury mechanisms; dynamic implantation; orthopaedics biomechnanics
Dr. Ali Kiapour

E-Mail Website
Guest Editor
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Interests: spine biomechanics; mechanobiology; orthopedics; 3D printing technology; finite element analysis; in vitro studies
Prof. Dr. Ali Fahir Özer

E-Mail Website
Guest Editor
Neurosurgery Department, Koc University School of Medicine, Istanbul 34450, Turkey
Interests: dynamic stabilization of spine; biomechanics of spine; degenerative spine

Special Issue Information

Dear Colleagues,

Biomechanics, the application of mechanical principles to living organisms, helps us to understand how all the bony and soft spinal components contribute individually and together to ensure spinal stability, and how traumas, tumours and degenerative disorders exert destabilizing effects. This Special Issue focuses on recent progress in spine biomechanics. It includes a collection of articles and research papers that present new insights, methods, and technologies related to understanding the mechanical behavior of the spine. This Special Issue covers a broad range of topics, including spine modeling, spinal implant design, AI research and their implementation in spine biomechanics, spinal injury mechanisms, spinal loading and response, and spine rehabilitation.

Dr. Deniz Ufuk Erbulut
Dr. Ali Kiapour
Prof. Dr. Ali Fahir Özer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spinal implant
  • AI research and their application in spine biomechanics
  • FE modeling
  • spinal injury mechanisms

Published Papers (2 papers)

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Research

13 pages, 12222 KiB  
Article
Modeling the Effect of Annulus Fibrosus Stiffness on the Stressed State of a Vertebral L1 Body and Nucleus Pulposus
by Oleg Ardatov, Jolita Pachaleva, Viktorija Aleksiuk, Algirdas Maknickas, Ilona Uzieliene, Raminta Vaiciuleviciute and Eiva Bernotiene
Bioengineering 2024, 11(4), 305; https://doi.org/10.3390/bioengineering11040305 - 24 Mar 2024
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Abstract
The investigation examines the transference of stiffness from intervertebral discs (IVDs) to the lumbar body of the L1 vertebra and the interactions among adjacent tissues. A computational model of the vertebra was developed, considering parameters such as cortical bone thickness, trabecular bone elasticity, [...] Read more.
The investigation examines the transference of stiffness from intervertebral discs (IVDs) to the lumbar body of the L1 vertebra and the interactions among adjacent tissues. A computational model of the vertebra was developed, considering parameters such as cortical bone thickness, trabecular bone elasticity, and the nonlinear response of the nucleus pulposus to external loading. A nonlinear dynamic analysis was performed, revealing certain trends: a heightened stiffness of the annulus fibrosus correlates with a significant reduction in the vertebral body’s ability to withstand external loading. At a supplied displacement of 6 mm, the vertebra with a degenerative disc reached its yielding point, whereas the vertebrae with a healthy annulus fibrosus exhibited a strength capacity exceeding 20%. The obtained findings and proposed methodology are potentially useful for biomedical engineers and clinical specialists in evaluating the condition of the annulus fibrosus and predicting its influence on the bone components of the spinal system. Full article
(This article belongs to the Special Issue Recent Development in Spine Biomechanics)
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15 pages, 3823 KiB  
Article
In Vitro Wear of a Novel Vitamin E Crosslinked Polyethylene Lumbar Total Joint Replacement
by Ryan L. Siskey, Ronald V. Yarbrough, Hannah Spece, Scott D. Hodges, Steven C. Humphreys and Steven M. Kurtz
Bioengineering 2023, 10(10), 1198; https://doi.org/10.3390/bioengineering10101198 - 15 Oct 2023
Viewed by 1559
Abstract
Background: A novel, lumbar total joint replacement (TJR) design has been developed to treat degeneration across all three columns of the lumbar spine (anterior, middle, and posterior columns). Thus far, there has been no in vitro studies that establish the preclinical safety profile [...] Read more.
Background: A novel, lumbar total joint replacement (TJR) design has been developed to treat degeneration across all three columns of the lumbar spine (anterior, middle, and posterior columns). Thus far, there has been no in vitro studies that establish the preclinical safety profile of the vitamin E-stabilized highly crosslinked polyethylene (VE-HXLPE) lumbar TJR relative to historical lumbar anterior disc replacement for the known risks of wear and impingement faced by all motion preserving designs for the lumbar spine. Questions/Purpose: In this study we asked, (1) what is the wear performance of the VE-HXLPE lumbar TJR under ideal, clean conditions? (2) Is the wear performance of VE-HXLPE in lumbar TJR sensitive to more aggressive, abrasive conditions? (3) How does the VE-HXLPE lumbar TJR perform under impingement conditions? Method: A lumbar TJR with bilateral VE-HXLPE superior bearings and CoCr inferior bearings was evaluated under clean, impingement, and abrasive conditions. Clean and abrasive testing were guided by ISO 18192-1 and impingement was assessed as per ASTM F3295. For abrasive testing, CoCr components were scratched to simulate in vivo abrasion. The devices were tested for 10 million cycles (MC) under clean conditions, 5 MC under abrasion, and 1 MC under impingement. Result: Wear rates under clean and abrasive conditions were 1.2 ± 0.5 and 1.1 ± 0.6 mg/MC, respectively. The VE-HXLPE components demonstrated evidence of burnishing and multidirectional microscratching consistent with microabrasive conditions with the cobalt chromium spherical counterfaces. Under impingement, the wear rates ranged between 1.7 ± 1.1 (smallest size) and 3.9 ± 1.1 mg/MC (largest size). No functional or mechanical failure was observed across any of the wear modes. Conclusions: Overall, we found that that a VE-HXLPE-on-CoCr lumbar total joint replacement design met or exceeded the benchmarks established by traditional anterior disc replacements, with wear rates previously reported in the literature ranging between 1 and 15 mg/MC. Clinical Relevance: The potential clinical benefits of this novel TJR design, which avoids long-term facet complications through facet removal with a posterior approach, were found to be balanced by the in vitro tribological performance of the VE-HXLPE bearings. Our encouraging in vitro findings have supported initiating an FDA-regulated clinical trial for the design which is currently under way. Full article
(This article belongs to the Special Issue Recent Development in Spine Biomechanics)
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