The Application of Cutting Edge Technology of Microfluidics in the Mechanical Behavior of Blood

Dear Colleagues,

The application of the cutting-edge technology of microfluidics related to the origin, development, and future of microfluidics in the history of science,  and this topic first appeared in the journal Nature in 2006 (Whitesides G M., 2006). Simultaneously, discussions regarding the tool "Tissue engineering" (Langer R., and J.P. Vacanti, 1993) continued. The new biotechnology for the advancement of toxicology and drug production, "Microfluidic organ-on-a-chip", was independently developed in 2015 by two scientific groups (of Kaplon J. D. et al., and of Esch E.W. et al.). Major advances in the field of sensors are the result of the integration of "Tissue engineering" with "Microfluidics", "Microelectronics", and "Microfabrication" (Perestrelo A.R., 2015).

Now, when biomolecules, such as peptides, proteins, nucleic acids, etc., are analyzed and controlled in " Tissue engineering", "Biosensors" provide insights into the cells, monitoring signals which can be adapted to a 3D level. The "Body on a chip" could predict precise "cell–cell" and "cell–drug" responses (Perestrelo A.R., 2015). During the time of recent developments of Automatic Hematology, new research has been reproduced in the field of Micofluidics (Bene M. C., 2017). An original hybrid system for hemorheological and hemodynamic blood analysis has been constructed (Yeom E. et al., 2015).

Microfluidic devices can produce routine and individual laboratory blood tests, with considerable progress being made in the field of hemorheology, fluidic (flow) cytometry, the preparation of separated blood cells, and individual isolated blood cell investigations.

Advances in microfluidic technology could contribute to developments in the field, improving the disease states and prognosis of patients. Along with human health improvement, it is possible to determine the common biophysical and biomechanical properties of different blood cells in both patients who are healthy and those who have diseases. Added emphasis is placed on multiform platforms for effective cell separation and presentation. The precise micro-fluidic cell environment could be a gold standard blood test in the near future.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

1. Microfluid;
2. Hematology;
3. Cutting-Edge Technology;
4. Mechanical Behavior of Blood;
5. Blood

Dr. Elissaveta Zvetkova
Dr. Ivan Ivanov
Guest Editors

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