Special Issue "Bioinformatics Applications of MicroRNAs in Cancer Research"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Computing and Artificial Intelligence".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 607

Special Issue Editors

Prof. Dr. Giuseppe Sammarco
E-Mail Website
Guest Editor
Department of Health Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro CZ, Italy
Interests: general and colorectal surgery
Dipartiment of Computer Science, Università degli Studi di Torino, 10149 Torino, Italy
Interests: computational biology; systems biology; functional genomics
Department of Medical and Surgical Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro CZ, Italy
Interests: abdominal surgery; colorectal cancer; colorectal surgery; digestive surgery; miRNA; MMP (Matrix metalloproteinase); proctology; surgery; translational research
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Special Issue Information

Dear Colleagues,

In the last few years, the field of epigenetics has significantly expanded due to the discovery of new high-throughput microarray-based miRNA profiling platforms such as next-generation sequencing (NGS) that allow genome-wide microRNA (miRNA) and mRNA expression analyses.

miRNAs are a class of short endogenous single-stranded non-coding RNAs that are 18–25 nucleotides in length and are able to post-transcriptionally repress gene expression by binding to the 3’untranslated region (UTR) of their target mRNAs.

They were first discovered in 1993 as a developmental regulator of the nematode Caenorhabditis elegans. Since then, miRNAs have been found in different body fluids, such as serum, plasma, urine, saliva and tissues, and several studies have reported their roles in a variety of biological processes and immune responses, including angiogenesis, drug resistance and tumorigenesis.

Computational biology has improved our understanding and characterization of miRNAs. Bioinformatics and Systems Biology approaches have provided tools and pipelines to facilitate the discovery of novel miRNA loci and isoforms, as well as the characterization of miRNAs regulated genes and signaling pathways.

The aim of this Special Issue is to provide a series of state-of-the-art manuscripts, including both original contributions and review articles, in order to reach a complete understanding of the role of Bioinformatics Applications of MicroRNAs in Cancer Research.

Prof. Dr. Giuseppe Sammarco
Dr. Giulio Ferrero
Dr. Gaetano Gallo
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • microRNAs
  • small RNAs
  • cancer
  • gastrointestinal cancers
  • urologic cancers
  • gynecological cancers
  • bioinformatics
  • microbiome

Published Papers

There is no accepted submissions to this special issue at this moment.
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