New Challenges and Future Perspectives in the Treatment of Central White Matter Pathologies

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 180

Special Issue Editors

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Guest Editor
Department of Physiology and Biochemistry, University of Malta, 2080 Msida, Malta
Interests: stroke and neurovascular coupling; white matter injury; brain injury and repair; rodent models of stroke; two-photon imaging of live rodent brain; neuroprotection; spinal cord and traumatic brain injury
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, 2080 Msida, Malta
Interests: stroke; white matter injury; neonatal hypoxia ischemia; live brain slice imaging; electrophysiology; two-photon microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decade, there has been growing interest and important developments in the identification of effective targets for central white matter pathologies. The progress has been encouraged by enhancements in research methodologies that allow us to collect perspectives from various angles, alongside the imperative to gain a deeper comprehension of the interplay between these various mechanisms. In spite of the collaborative endeavors of the scientific community to comprehend these fundamental pathological processes, the creation of impactful treatments has not yet been achieved. Current treatment models primarily concentrate on relieving symptoms without addressing the fundamental pathology, making them ineffective in the advanced stages of the disease. The realm of white matter neurobiology and its associated ailments is progressively developing to address this gap in scientific knowledge. Driven by advancements in imaging technologies, molecular techniques, and cellular and animal models, investigations into the development, injury, and recovery of white matter has allowed for the dissemination of fresh knowledge regarding the progression of neurodegenerative white matter diseases.

In this Special Issue, we encourage researchers to offer papers summarizing the state of the art and the main challenges in the field of diseases that directly affect the white matter. We also encourage contributions that delve into future prospects and outline developments that this field will experience in the upcoming years. Relevant research areas are as follows:

  • What significant breakthroughs have shaped our understanding?
  • What challenges demand immediate attention?

The Guest Editors welcome all types of manuscripts published by the journal, which comprise original research articles, methodologies, brief research reports, reviews, and perspectives related to this wide field of neurobiology.

Prof. Dr. Mario Valentino
Dr. Christian Zammit
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • white matter injury
  • leukodystrophies
  • multiple sclerosis
  • lacunar stroke
  • ALS

Published Papers

This special issue is now open for submission.
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