Numerical and Mechanical Analysis in Biomedicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 10 November 2024 | Viewed by 135

Special Issue Editors

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Guest Editor
Nanoscience and Nanoengineering, South Dakota School of Mines and Technology, 501 East Saint Joseph Street, Rapid City, SD 57703, USA
Interests: biomechanical engineering; biomechanics; biomedical modeling; biomaterials; biomedical imaging; cell culture; immunoblotting; cell imaging; cell signaling; immunofluorescence

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Guest Editor
Department of Engineering, University of Perugia, 06125 Perugia, Italy
Interests: biomechanics; biomaterials; stress analysis; bioreactors; multiphysics

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Guest Editor
Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA 18015, USA
Interests: biomechanics; dynamic loading; modelling of cell motility; gait analysis
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Special Issue Information

Dear Colleagues,

Understanding pathology and treating diseases require detailed observations and analyses of research targets at multiple scales, from nano to macro. Most diseases arise due to imbalances in cell and tissue homeostasis which are affected by cell activity and differentiation. Cells can sense, respond, and adapt to mechanical stimuli, often differentiating between static and dynamic stimuli. Traditional mechanical processes applied to monolayers of cells, intact tissues, or engineered tissue structures can stimulate cell differentiation and promote metabolic changes. Cell differentiation and reproduction can promote tissue repair and regeneration, thereby impacting the treatment of tissues, organs, and systems within the body. Mechanobiological studies can help explain macroscopic pathogenesis from the microscopic level through cellular activities. These studies are further enhanced when coupled with advanced numerical analysis techniques, including but not limited to finite element analysis, computational fluid dynamics, multi-physics modeling, multi-scale modeling, agent-based modeling, network analyses, and artificial intelligence (AI)-based methodologies. Integration of these analytical tools with biomechanical and mechanobiological data can deepen our understanding and enable predictions of complex mechanobiological processes, which may lead to biomechanical or pharmacomechanical solutions to treat a wide variety of diseases.

This Special Issue aims to explore the potential of numerical and mechanical analyses in the biomedical field to accelerate the understanding of pathogenesis, accelerate drug development, and accelerate the development of novel disease treatments. We welcome numerical studies, experimental studies, and comprehensive reviews.

Dr. Scott T. Wood
Dr. Elisabetta Zanetti
Prof. Dr. Arkady Voloshin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mechanobiological therapy
  • mechanical analysis in biomedicine
  • cell culture
  • biomechanics
  • cell differentiation
  • mechanotransduction
  • numerical techniques in biomedicine

Published Papers

This special issue is now open for submission.
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