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Advances in Comparative Oncology: Naturally Developing Tumors in Animals for...
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Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 8846

Special Issue Editors

Dr. Marcella Massimini

E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy
Interests: comparative oncology; molecular pathways and biological markers involved in carcinogenesis
Prof. Dr. Mariarita Romanucci

E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy
Interests: veterinary and comparative oncology; heat shock/stress proteins in cancer
Prof. Dr. Leonardo Della Salda

E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy
Interests: oncology; dermato-histopathology and ultrastructural pathology in animals
Prof. Dr. Carlos E. Alvarez

E-Mail Website
Guest Editor
Center for Clinical and Translational Research, The Abigail Wexner Research Instituteat Nationwide Children's Hospital; and Departments of Pediatrics and Veterinary Clinical Sciences, The Ohio State University Colleges of Medicine and Veterinary Medicine, Columbus, OH, USA
Interests: canine complex genetics; human-canine comparative genomics; animal models of disease; oncology; behavior; psychopathology; pleiotropy; molecular pharmacology

Special Issue Information

Dear Colleagues,

Comparative oncology is a rapidly expanding field of study focusing on naturally developing tumors in animals for increasing knowledge in cancer biology and therapy. Research studies from comparative oncology can integrate scientific findings to better understand the pathobiology of cancer, investigate cancer-associated genes and proteins, and translate these findings into novel therapies to benefit both animals and humans, in a One Health perspective.

Thus, the goal of this Special Issue is to synthesize our current knowledge of animal tumors with a comparative oncology approach, and to stimulate interdisciplinary collaborative research efforts aimed at advancing both animal and human health.

For this Special Issue, we invite scientists to submit original research articles on any aspect concerning comparative oncology, with particular interest on canine and feline tumors, as a group of naturally occurring malignancies similar in tumor biology and behavior to human cancers. Both biology-based and translational research studies, as well as review articles, are welcome.

Dr. Marcella Massimini
Prof. Dr. Mariarita Romanucci
Prof. Dr. Leonardo Della Salda
Prof. Dr. Carlos E. Alvarez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animals
  • cancer therapy
  • comparative oncology
  • naturally developing cancers
  • translational research
  • tumor biology

Published Papers (5 papers)

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Research

13 pages, 889 KiB  
Article
An Evaluation of Hemostatic Dysregulation in Canine Multicentric Lymphoma
by Maria Ludovica Messina, Fausto Quintavalla, Angelo Pasquale Giannuzzi, Tommaso Furlanello and Marco Caldin
Animals 2024, 14(3), 500; https://doi.org/10.3390/ani14030500 - 02 Feb 2024
Viewed by 1053
Abstract
Multiple hemostatic abnormalities are associated with paraneoplastic syndrome and some malignant tumors. Lymphoma is the most common hematopoietic neoplasm in dogs, sometimes associated with hemostatic changes. The objectives of this study were to evaluate the behavior of coagulation parameters in dogs with multicentric [...] Read more.
Multiple hemostatic abnormalities are associated with paraneoplastic syndrome and some malignant tumors. Lymphoma is the most common hematopoietic neoplasm in dogs, sometimes associated with hemostatic changes. The objectives of this study were to evaluate the behavior of coagulation parameters in dogs with multicentric lymphoma compared with diseased dogs without lymphoma, to separately evaluate the effect of immunophenotype (B lymphoma versus T lymphoma) on the variables of interest as well as the effect of disease stage (stage II to IV versus stage V). Specifically, a cross-sectional study was performed with a matched comparison group considering 170 dogs with B or T lymphoma (group 1) and 170 dogs with no lymphoma or other neoplastic processes but other diseases (group 0). Eight coagulation parameters were evaluated: platelet count (Plt), activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT), fibrinogen, fibrin/products of fibrinogen degradation (FDPs), fibrin D-dimers, and antithrombin (AT). Dogs with lymphoma showed prolonged PT and TT, decreased fibrinogen, increased FDP, and decreased Plt compared with group 0. The effect of disease stage was evaluated separately for dogs with stage II to IV lymphoma and dogs with stage V lymphoma; patients with stage II–IV lymphoma showed no significant differences, while in dogs with stage V lymphoma, a prolongation of PT and TT, a decrease in fibrinogen, an increase in FDPs and a decrease in Plt were found compared with the group 0. Finally, the comparison between B lymphoma and T lymphoma showed no significant differences in coagulation parameters between the two groups. Logistic regression analysis demonstrated that low fibrinogen and platelet levels were the most significant predictors of lymphoma in a cohort of canine patients. These hemostatic abnormalities in lymphoma appeared to be associated with the stage of the disease rather than the lymphoma immunophenotype. These findings pave the way for the possible scenario of lymphoma-associated fibrinolysis and the so far undescribed pattern of hyperfibrinolysis associated with the most severe stage of lymphoma. Full article
(This article belongs to the Special Issue Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy)
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13 pages, 1435 KiB  
Article
Is Osteopontin a Good Marker for Bone Metastasis in Canine Mammary Gland Tumor and Prostate Cancer?
by Caroline Grisoni Sanchez, Marxa Leão Figueiredo, Laíza de Sartori Camargo, Luiz Guilherme Dercore Benevenuto, Zara Alves Lacerda and Carlos Eduardo Fonseca-Alves
Animals 2023, 13(20), 3211; https://doi.org/10.3390/ani13203211 - 14 Oct 2023
Cited by 1 | Viewed by 1140
Abstract
Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, [...] Read more.
Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, but no prior research has investigated the association between OPN expression and the metastasis of canine mammary gland tumors (MGTs) and prostate cancer (PC). Therefore, we investigated OPN expression in MGTs and PC samples from 50 canine patients with or without metastasis (bone vs. other sites). Higher OPN expression was detected in primary tumor samples from animals with bone metastasis than in those without bone involvement (p = 0.0321). In MGT samples, a significantly lower survival rate was observed in patients with higher OPN expression (p = 0.0171). In animals with PC, there was a strong trend toward lower survival in animals with positive OPN expression; however, this trend was not statistically significant (p = 0.0779). From these findings, it can be concluded that OPN may be a promising target for future MGTs and PC studies because of its role in enhancing cell invasion and metastasis. Full article
(This article belongs to the Special Issue Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy)
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16 pages, 3445 KiB  
Article
Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds—A Preliminary Study
by Sungryong Kim, Namphil Kim, Hyo-Min Kang, Hye-Jin Jang, Amos Chungwon Lee and Ki-Jeong Na
Animals 2023, 13(18), 2846; https://doi.org/10.3390/ani13182846 - 07 Sep 2023
Viewed by 1332
Abstract
Canine lymphoma (CL) is one of the most common malignant tumors in dogs. The cause of CL remains unclear. Genetic mutations that have been suggested as possible causes of CL are not fully understood. Whole-exome sequencing (WES) is a time- and cost-effective method [...] Read more.
Canine lymphoma (CL) is one of the most common malignant tumors in dogs. The cause of CL remains unclear. Genetic mutations that have been suggested as possible causes of CL are not fully understood. Whole-exome sequencing (WES) is a time- and cost-effective method for detecting genetic variants targeting only the protein-coding regions (exons) that are part of the entire genome region. A total of eight patients with B-cell lymphomas were recruited, and WES analysis was performed on whole blood and lymph node aspirate samples from each patient. A total of 17 somatic variants (GOLIM4, ITM2B, STN1, UNC79, PLEKHG4, BRF1, ENSCAFG00845007156, SEMA6B, DSC1, TNFAIP1, MYLK3, WAPL, ADORA2B, LOXHD1, GP6, AZIN1, and NCSTN) with moderate to high impact were identified by WES analysis. Through a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of 17 genes with somatic mutations, a total of 16 pathways were identified. Overall, the somatic mutations identified in this study suggest novel candidate mutations for CL, and further studies are needed to confirm the role of these mutations. Full article
(This article belongs to the Special Issue Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy)
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11 pages, 267 KiB  
Article
Psychological Stress Is Associated with Increased Cancer Risk in Dogs
by Isain Zapata, Alexander W. Eyre and Carlos E. Alvarez
Animals 2023, 13(11), 1869; https://doi.org/10.3390/ani13111869 - 03 Jun 2023
Viewed by 2926
Abstract
Although there is evidence that psychological stress may be associated with increased cancer risk, the effect of stress on cancer risk is difficult to study, both in humans, due to socioeconomic factors, and in animal models, due to questionable biological relevance. Here, we [...] Read more.
Although there is evidence that psychological stress may be associated with increased cancer risk, the effect of stress on cancer risk is difficult to study, both in humans, due to socioeconomic factors, and in animal models, due to questionable biological relevance. Here, we test whether heritable canine temperament that increases psychological stress is associated with cancer risk. The study data are breed-specific averages of incidences of multiple cancer types and of temperament classes. The latter are derived from a latent class analysis of behavioral questionnaires completed by owners (C-BARQ). We thus classified the dogs according to whether they are calm vs. reactive within and across breeds. Using meta-analysis approaches, we modeled the risk of multiple cancer types in calm vs. reactive dogs. We adjusted for breed averages of body mass and lifespan, which are common confounders that impact cancer. Our study confirms that body size has a significant effect of on risk of multiple types of cancers in dogs and shows for the first time that temperament also has a moderate effect. These findings suggest dog models of heritable psychological stress are suitable for molecular epidemiological and translational studies on its effects on cancer risk. Full article
(This article belongs to the Special Issue Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy)
12 pages, 1020 KiB  
Article
Validation of p53 Immunohistochemistry (PAb240 Clone) in Canine Tumors with Next-Generation Sequencing (NGS) Analysis
by Barbara Brunetti, Dario de Biase, Giulia Dellapina, Luisa Vera Muscatello, Francesco Ingravalle, Giorgia Tura and Barbara Bacci
Animals 2023, 13(5), 899; https://doi.org/10.3390/ani13050899 - 01 Mar 2023
Viewed by 1422
Abstract
In human medicine, p53 immunohistochemistry (IHC) is a common method that is used for the identification of tumors with TP53 mutations. In veterinary medicine, several studies have performed IHC for p53 in canine tumors, but it is not known how well it actually [...] Read more.
In human medicine, p53 immunohistochemistry (IHC) is a common method that is used for the identification of tumors with TP53 mutations. In veterinary medicine, several studies have performed IHC for p53 in canine tumors, but it is not known how well it actually predicts the mutation. The aim of this study was to estimate the accuracy of the IHC method for p53 (clone PAb240) using a lab-developed NGS panel to analyze TP53 mutations in a subset of malignant tumors in dogs. A total of 176 tumors were analyzed with IHC and then 41 were subjected to NGS analysis; among them, 15 were IHC positive and 26 were negative, and 16 out of 41 (39%) were found to be inadequate for NGS analysis. Excluding the non-evaluable cases at NGS, of the remaining eight IHC-positive cases, six were mutants and two were wild-type. Among the 17 IHC-negative cases, 13 were wild type, and 4 were mutants. The sensitivity was 60%, specificity was 86.7%, and the accuracy was 76%. These results suggest that when using IHC for p53 with this specific antibody to predict mutation, up to 25% wrong predictions can be expected. Full article
(This article belongs to the Special Issue Advances in Comparative Oncology: Naturally Developing Tumors in Animals for Investigating Cancer Biology and Therapy)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Giant Cell Tumor of bone in animals: a rare bone tumor not yet well defined. An Immunohistochemical study.
Author: Leonardi
Highlights: Our goal is to try to make scientific input and new conclusions on the exact nature of one of the rarest bone tumors in animals. Kws: Giant cell tumor, Bone, Cats, dogs, Immunohistochemistry

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