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Animals
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Genetics and Breeding Advances in Poultry Health and Production
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Genetics and Breeding Advances in Poultry Health and Production

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 3430

Special Issue Editors

Dr. Jibin Zhang

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Guest Editor
Department of Anatomic Pathology, Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA
Interests: poultry; molecular genetics; immunogenetics; bioinformatics
Prof. Dr. Kichoon Lee

E-Mail Website
Guest Editor
Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
Interests: poultry; molecular biology; functional genomics; growth biology; muscle development; muscle growth
Dr. Hongyan Sun

E-Mail Website
Guest Editor
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Interests: poultry breeding and genetics; disease resistance; poultry production

Special Issue Information

Dear Colleagues,

The past few decades have seen remarkable improvements of poultry production, such as faster growth and more egg production, driven largely by genetic selection and breeding. However, there are still concerning issues for the modern poultry industry, such as compromised meat quality and poultry health due to rapid growth, reduced tolerance to heat stress, and great loss due to infectious diseases, which are exacerbated by irreconcilable phenotype traits, noticeable global climate changes, and emerging and evolving pathogen strains. The complex genetic regulation networks consisting of alternative splicing, transcriptional factor binding, gene rearrangement, mutations and copy number changes, chromatin conformation and interactions, epigenetic changes, and diverse cellular interactions (e.g., host–pathogen interactions) pose a great challenge to improve these quantitative traits. Fortunately, with advanced techniques such as gene editing, CRISPR screening, high-throughput sequencing and machine learning, we can now solve these complex issues with improved precision and find core information among the big data with enhanced accuracy. With the aim of presenting current advances and enlightening thoughts on future prospects, this Special Issue will present a collection of papers illustrating the application of these techniques in understanding molecular mechanisms underlying critical phenotypes such as muscle growth, stress tolerance and disease resistance.

Dr. Jibin Zhang
Prof. Dr. Kichoon Lee
Dr. Hongyan Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics and breeding
  • gene editing
  • bioinformatics
  • immunology
  • muscle growth
  • disease resistance
  • stress tolerance

Published Papers (3 papers)

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Research

19 pages, 6160 KiB  
Article
Molecular Mechanisms of circRNA–miRNA–mRNA Interactions in the Regulation of Goose Liver Development
by Shuibing Liu, Chuan Li, Xiaolong Hu, Huirong Mao, Sanfeng Liu and Biao Chen
Animals 2024, 14(6), 839; https://doi.org/10.3390/ani14060839 - 08 Mar 2024
Viewed by 746
Abstract
The liver, a crucial metabolic organ in animals, is responsible for the synthesis, breakdown, and transport of lipids. However, the regulatory mechanisms involving both coding and noncoding RNAs that oversee the development of the goose liver remain elusive. This study aimed to fill [...] Read more.
The liver, a crucial metabolic organ in animals, is responsible for the synthesis, breakdown, and transport of lipids. However, the regulatory mechanisms involving both coding and noncoding RNAs that oversee the development of the goose liver remain elusive. This study aimed to fill this knowledge gap by conducting RNA-seq to profile the expression of circular RNAs (circRNAs) and microRNAs (miRNAs) during goose liver development. We analyzed circRNAs in liver samples from Sichuan white geese at three developmental stages: posthatching day 0, 10 weeks (fast growth stage), and 30 weeks (sexual maturation stage). Our findings revealed 11,079 circRNAs and 994 miRNAs, among which the differentially expressed circRNAs and miRNAs were significantly enriched in pathways such as fatty acid biosynthesis, degradation, and metabolism. Further analysis of the target genes of the differentially expressed miRNAs revealed enrichment in pathways related to fatty acid biosynthesis, metabolism, PPAR signaling, DNA replication, and the cell cycle. We also established circRNA–miRNA–mRNA regulatory networks, identifying key regulatory factors and miRNAs. In conclusion, our study offers valuable insights into the complex interplay of circRNA–miRNA–mRNA interactions during goose liver development, and illuminates the molecular pathways that regulate this vital life function. Full article
(This article belongs to the Special Issue Genetics and Breeding Advances in Poultry Health and Production)
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11 pages, 1224 KiB  
Communication
Effects of Heat Stress and Lipopolysaccharides on Gene Expression in Chicken Immune Cells
by Guang Yang, Xinyi Zhou, Shutao Chen, Anfang Liu, Lingbin Liu, Haiwei Wang, Qigui Wang and Xi Lan
Animals 2024, 14(4), 532; https://doi.org/10.3390/ani14040532 - 06 Feb 2024
Viewed by 550
Abstract
Prolonged exposure to high temperatures and humidity can trigger heat stress in animals, leading to subsequent immune suppression. Lipopolysaccharides (LPSs) act as upstream regulators closely linked to heat stress, contributing to their immunosuppressive effects. After an initial examination of transcriptome sequencing data from [...] Read more.
Prolonged exposure to high temperatures and humidity can trigger heat stress in animals, leading to subsequent immune suppression. Lipopolysaccharides (LPSs) act as upstream regulators closely linked to heat stress, contributing to their immunosuppressive effects. After an initial examination of transcriptome sequencing data from individual samples, 48 genes displaying interactions were found to potentially be associated with heat stress. Subsequently, to delve deeper into this association, we gathered chicken bone marrow dendritic cells (BMDCs). We combined heat stress with lipopolysaccharides and utilized a 48 × 48 Fluidigm IFC quantitative microarray to analyze the patterns of gene changes under various treatment conditions. The results of the study revealed that the combination of heat stress and LPSs in a coinfection led to reduced expressions of CRHR1, MEOX1, and MOV10L1. These differentially expressed genes triggered a pro-inflammatory response within cells via the MAPK and IL-17 signaling pathways. This response, in turn, affected the intensity and duration of inflammation when experiencing synergistic stimulation. Therefore, LPSs exacerbate the immunosuppressive effects of heat stress and prolong cellular adaptation to stress. The combination of heat stress and LPS stimulation induced a cellular inflammatory response through pathways involving cAMP, IL-17, MAPK, and others, consequently leading to decreased expression levels of CRHR1, MEOX1, and MOV10L1. Full article
(This article belongs to the Special Issue Genetics and Breeding Advances in Poultry Health and Production)
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13 pages, 2134 KiB  
Article
Identification of Runs of Homozygosity Islands and Functional Variants in Wenchang Chicken
by Shuaishuai Tian, Wendan Tang, Ziqi Zhong, Ziyi Wang, Xinfeng Xie, Hong Liu, Fuwen Chen, Jiaxin Liu, Yuxin Han, Yao Qin, Zhen Tan and Qian Xiao
Animals 2023, 13(10), 1645; https://doi.org/10.3390/ani13101645 - 15 May 2023
Cited by 2 | Viewed by 1395
Abstract
Wenchang chickens, a native breed in the Hainan province of China, are famous for their meat quality and adaptability to tropical conditions. For effective management and conservation, in the present study, we systematically investigated the characteristics of genetic variations and runs of homozygosity [...] Read more.
Wenchang chickens, a native breed in the Hainan province of China, are famous for their meat quality and adaptability to tropical conditions. For effective management and conservation, in the present study, we systematically investigated the characteristics of genetic variations and runs of homozygosity (ROH) along the genome using re-sequenced whole-genome sequencing data from 235 Wenchang chickens. A total of 16,511,769 single nucleotide polymorphisms (SNPs) and 53,506 ROH segments were identified in all individuals, and the ROH of Wenchang chicken were mainly composed of short segments (0–1 megabases (Mb)). On average, 5.664% of the genome was located in ROH segments across the Wenchang chicken samples. According to several parameters, the genetic diversity of the Wenchang chicken was relatively high. The average inbreeding coefficient of Wenchang chickens based on FHOM, FGRM, and FROH was 0.060 ± 0.014, 0.561 ± 0.020, and 0.0566 ± 0.01, respectively. A total of 19 ROH islands containing 393 genes were detected on 9 different autosomes. Some of these genes were putatively associated with growth performance (AMY1a), stress resistance (THEMIS2, PIK3C2B), meat traits (MBTPS1, DLK1, and EPS8L2), and fat deposition (LANCL2, PPARγ). These findings provide a better understanding of the degree of inbreeding in Wenchang chickens and the hereditary basis of the characteristics shaped under selection. These results are valuable for the future breeding, conservation, and utilization of Wenchang and other chicken breeds. Full article
(This article belongs to the Special Issue Genetics and Breeding Advances in Poultry Health and Production)
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