Perspectives of Pluripotent Stem Cells in Animals
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 147
Special Issue Editor
Interests: animals; pluripotent stem cells (PSCs); embryonic stem cells (ESCs); cell differentiation; in vitro cell culture
Special Issue Information
Dear Colleagues,
The in vitro derivation of differentiated cell lineages from pluripotent stem cells (PSCs) has emerged as an exciting strategy for obtaining functional cells. Due to their unlimited proliferation capacity and high differentiation potential, PSCs may be induced to differentiate into cell types from the three germ layers. This remarkable capacity has settled PSCs as one of the most promising cell sources for regenerative and biotechnological applications in human and veterinary medicine. Initially, PSCs mainly referred to embryonic stem cells (ESCs) derived from the inner cell mass (ICM) of embryos. However, ethical dilemmas underlying the destruction of human embryos and technically limited processes for generating domestic animal ESCs, have restricted its use. Alternatively, the development of induced pluripotent stem cells (iPSCs) has revolutionized the potential application of in vitro cell differentiation for animal applications. However, some of the challenges to developing PSC-based biotechnological applications include 1) labor-intensive processes for the derivation of PSCs, 2) large-scale production in a laboratory setting, 3) derivation of host-specific for transplantation, and 4) efficient differentiation of functional PSC-derived cells.
The aim of this Special Issue is to present original research and reviews on experimental approaches for the derivation of PSCs and the differentiation of PSC-derived cells in domestic and wild animals.
Dr. Oscar A. Peralta
Guest Editor
Manuscript Submission Information
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Keywords
- embryonic stem cells
- induced pluripotent stem cells
- reprogramming
- cell differentiation
- pluripotency
- in vitro cell culture
