Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.2
3.0
Journals
Animals
Special Issues
Cancer Immunotherapy Research in Veterinary Medicine
share announcement

Cancer Immunotherapy Research in Veterinary Medicine

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 14 June 2024 | Viewed by 1772

Special Issue Editors

Dr. Francesca Millanta

E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Pisa, Pisa, Italy
Interests: veterinary oncology; histopathology; veterinary general pathology; comparative pathology; cancer biomarkers; cancer immunology
Dr. Francesca Parisi

E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Pisa, 56126 Pisa, Italy
Interests: veterinary pathology; comparative pathology; veterinary oncology; histopathology; cancer immunology; cancer biomarkers; veterinary anatomic pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunotherapy has revolutionized cancer treatment and has become an increasingly important approach in human oncology. The main fields of immunotherapy include the study of the immune system role in tumor progression and their dynamic interaction, the tumor microenvironment, the development, and the use of therapies stimulating the immune system to elicit an anti-tumoral response. Based on the underlying mechanism, different categories of immunotherapy have been developed in cancer treatment, such as cancer vaccines, immune checkpoint inhibitors (es PD-1 and CTLA-4), adoptive transfer of engineered cells (such as T-cells, natural killer cells or macrophages), cytokine therapies, monoclonal antibodies as therapeutic agents, and oncolytic virotherapy.

The purpose of this Special Issue is to focus on immunotherapy approaches in veterinary medicine, involving pathological, clinical, and translational studies on immunotherapy biomarkers, immunology signaling pathways, and novel immunotherapies.

Dr. Francesca Millanta
Dr. Francesca Parisi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • immunobiomarkers
  • immunotherapy
  • immune signal pathways
  • immune system
  • veterinary oncology

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

25 pages, 2846 KiB  
Article
Comparison of Nucleosome, Ferritin and LDH Levels in Blood with Clinical Response before and after Electrochemotherapy Combined with IL-12 Gene Electrotransfer for the Treatment of Mast Cell Tumours in Dogs
by Maša Vilfan, Urša Lampreht Tratar, Nina Milevoj, Alenka Nemec Svete, Maja Čemažar, Gregor Serša and Nataša Tozon
Animals 2024, 14(3), 438; https://doi.org/10.3390/ani14030438 - 29 Jan 2024
Viewed by 1315
Abstract
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to this treatment have not yet been investigated. [...] Read more.
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to this treatment have not yet been investigated. The aim of this study was to determine the plasma nucleosome and serum ferritin concentrations, as well as the lactate dehydrogenase (LDH) activity, in the serum of treated patients before and one and six months after treatment to evaluate their utility as potential biomarkers that could predict response to the combined treatment. The study was conducted in 48 patients with a total of 86 MCTs that we treated with the combined treatment. The blood samples used for analysing the potential predictive biomarkers were taken before treatment and one and six months after treatment, when the response to treatment was also assessed. The Nu. Q® Vet Cancer Test, the Canine Ferritin ELISA Kit, and the RX Daytona+ automated biochemical analyser were used to analyse the blood samples. The results showed that the plasma nucleosome concentration (before treatment (BT): 32.84 ng/mL (median); one month after treatment (1 M AT): 58.89 ng/mL (median); p = 0.010) and serum LDH activity (BT: 59.75 U/L (median); 1 M AT: 107.5 U/L (median); p = 0.012) increased significantly one month after treatment and that the increase correlated significantly with the presence of a more pronounced local reaction (necrosis, swelling, etc.) at that time point for both markers (nucleosome: BT (necrosis): 21.61 ng/mL (median); 1 M AT (necrosis): 69.92 ng/mL (median), p = 0.030; LDH: BT (necrosis): 54.75 U/L (median); 1 M AT (necrosis): 100.3 U/L (median), p = 0.048). Therefore, both the plasma nucleosome concentration and serum LDH activity could serve as early indicators of the effect of the treatment. In this context, the serum ferritin concentration showed no significant predictive potential for treatment response (p > 0.999 for all comparisons). In conclusion, this study provides some new and important observations on the use of predictive biomarkers in veterinary oncology. Furthermore, it emphasises the need for the continued identification and validation of potential predictive biomarkers in dogs with MCT and other malignancies undergoing ECT treatment in combination with IL-12 GET to ultimately improve treatment outcomes. Full article
(This article belongs to the Special Issue Cancer Immunotherapy Research in Veterinary Medicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: HER-2 and HER-3 expression in canine melanomas: correlation to prognostic parameters and possible therapeutic implications
Authors: Francesca Millanta; Francesca Parisi; Alessandro Poli; Arianna Pecorari; Luigi Aurisicchio
Affiliation: Department of Veterinary Sciences, University of Pisa Evvivax, Rome, Italy

Back to TopTop