Second Edition of Fasciolosis and Gastrointestinal Helminthiasis of Ruminants and Equids

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 558

Special Issue Editor


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Guest Editor
UMR Infectiologie et Santé Publique, INRAE & University of Tours, 37380 Nouzilly, France
Interests: eco-epidemiology of helminths; anthelmintics; philosophy of animal diseases; sociology of farming
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Special Issue Information

Dear Colleagues,

Gastro-intestinal and liver helminths are a major health problem, particularly for grazing herbivores. The first Special Issue on the same topic did not cover all the fields of research in this area, driving the publication of this second Special Issue. We may expect that the use of pasture as a natural source of feed will be maintained or even increased due to the consumer expectations for naturalness. The use of available anthelmintics has proved efficient for decades, but resistance to anthelmintics has steadily increased in small ruminants and equids, and is nowadays also distributed in cattle. The stakeholders of husbandry then turned to alternative solutions such as breeding production animals for resistance, mostly against gastro-intestinal nematodes. The investigation for drugs based on new mechanisms is an avenue for the control of infection. The use of natural drugs derived from plants has also been promoted. The use of the new available drugs should be moderate and targeted to the animals in need of treatments if we want to avoid the appearance of resistance to these drugs. The management of pastures should be also included in control programs.

We are pleased to invite you to contribute this Special Issue searching for original and novel papers on the recent evolution of the prevalence of gastrointestinal and Fasciola infections, the ways to control them through an increase in host resistance, synthetic anthelmintics or natural substances, and the management of pastures.

This Special Issue aims to provide information on the recent findings in managing helminthiases in ruminants and equids.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Resistance of host to GIN or Fasciola;
  2. New mechanisms of drug action and control of GIN or Fasciola;
  3. Kinds of drugs for control: both in vivo and vitro studies addressing the anthelmintic potential of bio-active compounds from natural source, as well as synthetic compounds;
  4. Ways to use available drugs in a context of resistance and targeted selective treatments (TST);
  5. Parasite control in the environment (pasture management, snail control, etc.);
  6. Farmers’ vision of gastrointestinal nematode management.

We look forward to receiving your contributions.

Dr. Jacques Cabaret
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host resistance
  • anthelmintics
  • TST
  • Fasciola
  • gastrointestinal helminths

Published Papers (1 paper)

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Research

16 pages, 2343 KiB  
Article
Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus
by Livia Furtado Ximenes, Henety Nascimento Pinheiro, José Vilemar de Araújo Filho, Weibson Paz Pinheiro André, Flávia Oliveira Monteiro da Silva Abreu, Mayrla Rocha Lima Cardial, Debora de Souza Colares Maia Castelo-Branco, Ana Carolina Fonseca Lindoso Melo, Francisco Flávio da Silva Lopes, Selene Maia de Morais, Lorena Mayana Beserra de Oliveira and Claudia Maria Leal Bevilaqua
Animals 2024, 14(7), 1007; https://doi.org/10.3390/ani14071007 - 26 Mar 2024
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Abstract
The present study aimed to evaluate the effect of nanoemulsions using combined synthetic anthelmintics, thiabendazole (TBZ), levamisole (LEV), and ivermectin (IVM), with carvacryl acetate (CA) against Haemonchus contortus, and also tested the presence and absence of alginate (ALG). The anthelmintic effect of [...] Read more.
The present study aimed to evaluate the effect of nanoemulsions using combined synthetic anthelmintics, thiabendazole (TBZ), levamisole (LEV), and ivermectin (IVM), with carvacryl acetate (CA) against Haemonchus contortus, and also tested the presence and absence of alginate (ALG). The anthelmintic effect of the CA/TBZ nanoemulsion was evaluated in the egg hatch test (EHT). The effects of CA/IVM and CA/LEV nanoemulsions were evaluated in the larval development test (LDT). The emulsions CA/TBZ/ALG and CA/TBZ showed a multimodal profile, with most particles on the nanometric scale. The encapsulation efficiency in CA/TBZ/ALG was 80.25%, and that in CA/LEV/ALG was 89.73%. In the EHT, CA/TBZ and CA/TBZ/ALG showed mean combination indices (CIs) of 0.55 and 0.36, respectively, demonstrating synergism in both. In LDT, CA/IVM had an average CI of 0.75, and CA/LEV and CA/LEV/ALG showed CI values of 0.4 and 0.93, respectively. It was concluded that CA/TBZ showed a synergistic interaction, and CA/TBZ/ALG showed an enhanced effect. In addition, the matrix brought stability to the product, encouraging its improvement to obtain higher efficacy. Full article
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