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Animals
Special Issues
Immunogenetics for Livestock Husbandry and Breeding
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Immunogenetics for Livestock Husbandry and Breeding

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 3131

Special Issue Editors

Prof. Dr. Mehmet Ulas Cinar

E-Mail Website
Guest Editor
1. Department of Animal Science, Faculty of Agriculture, Erciyes University, Kayseri, Türkiye
2. College of Veterinary Medicine, Veterinary Microbiology and Pathology, Washington State University Pullman, Pullman, WA, USA
Interests: animal husbandry; livestock immunogenetics; cattle; sheep; molecular genetics
Dr. Muhammad Jasim Uddin

E-Mail Website
Guest Editor
College of Veterinary Medicine, Murdoch University, Murdoch 6150, Australia
Interests: host-pathogen interactions; animal science and production; immunology; genomics; infectious diseases
Prof. Dr. Bilal Akyüz

E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, Department of Genetics, Erciyes University, Kayseri, Türkiye
Interests: animal husbandry; immunogenetics and genetics of production traits; ruminants immunogenetic

Special Issue Information

Dear Colleagues,

The term ‘immunogenetics’ refers to the scientific discipline that studies the molecular and genetic basis of the immune response. Livestock producers have long recognized immunogenetics by noticing how some animals possess an inner strength to resist disease. Although all animals are exposed to the same environmental pathogens, some of them were less prone to disease.

Animals will publish a Special Issue that focuses on novel molecular technologies such as immune response genes and marker-assisted selection; recombinant proteins as antibacterial substances; gene-editing technology for disease-resistant animals or somatic gene therapy against diseases. The current issue aims to identify genetic information and use this information to enhance selection for healthier livestock and better public health, as well. We look forward to your manuscript submissions by the indicated deadline. Please contact us with any questions about this Special Issue.

Prof. Dr. Mehmet Ulas Cinar
Dr. Muhammad Jasim Uddin
Prof. Dr. Bilal Akyüz 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional genomics
  • genetics
  • livestock
  • zoonoses
  • genomic technologies
  • sustainable livestock production

Published Papers (2 papers)

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Research

17 pages, 4338 KiB  
Article
Transcriptome Sequencing Reveals That Intact Expression of the Chicken Endogenous Retrovirus chERV3 In Vitro Can Possibly Block the Key Innate Immune Pathway
by Xi Zhang, Tingting Xie, Xiaoqi Li, Min Feng, Guodong Mo, Qihong Zhang and Xiquan Zhang
Animals 2023, 13(17), 2720; https://doi.org/10.3390/ani13172720 - 26 Aug 2023
Viewed by 883
Abstract
Endogenous retroviruses (ERVs) are viral sequences that have integrated into the genomes of vertebrates. Our preliminary transcriptome sequencing analysis revealed that chERV3 is active and is located on chromosome 1:32602284–32615631. We hypothesized that chERV3 may have a role in the host innate immune [...] Read more.
Endogenous retroviruses (ERVs) are viral sequences that have integrated into the genomes of vertebrates. Our preliminary transcriptome sequencing analysis revealed that chERV3 is active and is located on chromosome 1:32602284–32615631. We hypothesized that chERV3 may have a role in the host innate immune response to viral infection. In this study, using reverse genetics, we constructed the puc57-chERV3 full-length reverse cloning plasmid in vitro. We measured the p27 content in culture supernatant by enzyme-linked immunosorbent assay (ELISA). Finally, transcriptome analysis was performed to analyze the function of chERV3 in innate immunity. The results showed that chERV3 may generate p27 viral particles. We found that compared to the negative control (NC) group (transfected with pMD18T-EGFP), the chERV3 group exhibited 2538 up-regulated differentially expressed genes (DEGs) and 1828 down-regulated DEGs at 24 hours (h) and 1752 up-regulated DEGs and 1282 down-regulated DEGs at 48 h. Based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, the down-regulated DEGs were enriched mainly in immune-related processes such as the inflammatory response, innate immune response, and Toll-like receptor signaling pathway. GSEA showed that the Toll-like receptor signaling pathway was suppressed by chERV3 at both time points. We hypothesized that chERV3 can influence the activation of the innate immune pathway by blocking the Toll-like receptor signaling pathway to achieve immune evasion. Full article
(This article belongs to the Special Issue Immunogenetics for Livestock Husbandry and Breeding)
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14 pages, 845 KiB  
Article
Polymorphisms in Pattern Recognition Receptor Genes Are Associated with Respiratory Disease Severity in Pig Farms
by Kasumi Suzuki, Hiroki Shinkai, Gou Yoshioka, Toshimi Matsumoto, Takato Takenouchi, Junji Tanaka, Masanori Shimizu, Haruki Kitazawa and Hirohide Uenishi
Animals 2022, 12(22), 3163; https://doi.org/10.3390/ani12223163 - 16 Nov 2022
Cited by 2 | Viewed by 1411
Abstract
Reduced productivity caused by infections, particularly respiratory diseases, is a serious problem in pig farming. We have previously reported polymorphisms in porcine pattern recognition receptor genes affecting molecular functions and demonstrated that the 2197A/C polymorphism in the nucleotide-binding oligomerization domain containing 2 ( [...] Read more.
Reduced productivity caused by infections, particularly respiratory diseases, is a serious problem in pig farming. We have previously reported polymorphisms in porcine pattern recognition receptor genes affecting molecular functions and demonstrated that the 2197A/C polymorphism in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene influences porcine circovirus 2-induced mortality. Here, we investigated how these polymorphisms affect respiratory disease-induced lesions, using samples from a slaughterhouse dealing with pigs from two farms. Lung lesions were evaluated using two scoring systems, Goodwin (GW) and slaughterhouse pleuritis evaluation system (SPES), to determine the influence of Mycoplasma hyopneumoniae (Mhp) and Actinobacillus pleuropneumoniae (App), respectively. SPES scores were significantly higher when the 1205T allele of Toll-like receptor 5 (TLR5-1205T), rather than TLR5-1205C, was present. On the farm with more severe Mhp invasion, lower GW lesion scores were significantly associated with the presence of the NOD-like receptor family pyrin domain containing 3 (NLRP3)-2906G allele; where App invasion was worse, lower SPES scores were significantly associated with the presence of the NOD2-2197C allele. Combinations of polymorphisms in pattern recognition receptor genes can therefore be utilized for breeding for resistance against respiratory diseases in pigs. DNA markers of these polymorphisms can thus be used to improve productivity by reducing respiratory diseases due to bacterial pathogens in pig livestock. Full article
(This article belongs to the Special Issue Immunogenetics for Livestock Husbandry and Breeding)
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