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Animals
Special Issues
Canine and Feline Endocrinology: Research Progress and Challenges
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Canine and Feline Endocrinology: Research Progress and Challenges

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Physiology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 2230

Special Issue Editors

Dr. Rodolfo Oliveira Leal

E-Mail Website
Guest Editor
1. CIISA – Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal
Interests: canine and feline endocrinology; gastroenterology; canine leishmaniosis;
Dr. Francesca Del Baldo

E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, Italy
Interests: glucose; insulin; diabetes mellitus; hyperadrenocorticism; hypoadrenocorticism; cortisol; adrenal masses; monitoring and treatment of canine and feline endocrine diseases

Special Issue Information

Dear Colleagues,

Endocrinology is a well-recognized subfield of Veterinary Internal Medicine, accounting for a relevant percentage of cases in daily practice. With the advent of new therapeutic approaches (such as new insulin therapies), monitoring strategies (for instance, the current use of continuous glucose monitoring systems for diabetic dogs and cats), genetic research and diagnostic tests (such as the use of UCCR in Addison’s disease) highlight the constant research progress of this field. This Special Issue focuses on the current trends of veterinary endocrinology, pointing to recent novelties and current challenges in well-known diseases.

Authors are invited to submit original research, case reports and review articles focusing on etiology, diagnosis, therapy, monitoring and/or prognosis of different topics of canine and feline veterinary endocrinology, including (but not limited to):

  1. Diabetes Mellitus;
  2. Hyper- and hypocortisolism;
  3. Hyper- and Hypocalcemia;
  4. Pheochromocytoma;
  5. Hypo- and Hyperthyroidism;
  6. Insulinoma;
  7. Pituitary tumors;
  8. Gastrointestinal endocrine tumors;
  9. Insulin therapies;
  10. Multiendocrine tumors;
  11. Hyper- and hypoaldosteronism.

We look forward to receiving your contributions.

Dr. Rodolfo Oliveira Leal
Dr. Francesca Del Baldo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • canine endocrine diseases
  • feline endocrine diseases
  • thyroid gland
  • parathyroid gland
  • adrenal glands
  • pancreas
  • insulin
  • continuous glucose monitoring systems
  • pituitary
  • endocrine tumors

Published Papers (2 papers)

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Research

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15 pages, 670 KiB  
Article
Prevalence of Systemic Hypertension and Control of Systolic Blood Pressure in a Cohort of 14 Dogs with Adrenal-Dependent Hypercortisolism during the First Year of Trilostane Treatment or after Adrenalectomy
by Paula García San José, María Dolores Pérez-Alenza, Daniel Alonso-Miguel, Sandra González Sanz and Carolina Arenas Bermejo
Animals 2024, 14(3), 511; https://doi.org/10.3390/ani14030511 - 03 Feb 2024
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Abstract
Hypercortisolism in dogs is frequently associated with systemic hypertension (SH). However, there are no studies evaluating the changes in systolic blood pressure (SBP) in dogs with adrenal-dependent hypercortisolism (ADH) during trilostane treatment or after adrenalectomy and their response to antihypertensive treatments. For this [...] Read more.
Hypercortisolism in dogs is frequently associated with systemic hypertension (SH). However, there are no studies evaluating the changes in systolic blood pressure (SBP) in dogs with adrenal-dependent hypercortisolism (ADH) during trilostane treatment or after adrenalectomy and their response to antihypertensive treatments. For this reason, the objectives of this study were to evaluate the changes in SBP in dogs with ADH during the first year of trilostane treatment or after adrenalectomy, the relation with clinical control of hypercortisolism and certain laboratory parameters, and the response to antihypertensive drugs. Fourteen dogs newly diagnosed with ADH were prospectively included and evaluated at diagnosis (T0) and 1, 3, 6, and 12 months after (T1, T3, T6, and T12, respectively). Dogs were classified as hypertensive (HT; SBP ≥ 160 mmHg) and non-hypertensive. In HT dogs, benazepril was considered as the first-line drug, and, if necessary, amlodipine was prescribed. The prevalence of SH at T0 was 79%, and it was reduced to 25% at T12. Blood pressure (BP) was not associated with disease control or selected laboratory parameters at any endpoint. Only 22% of dogs with SH needed more than one drug to normalize their SBP. In all dogs surgically treated that were HT at T0, BP normalized at T3. Full article
(This article belongs to the Special Issue Canine and Feline Endocrinology: Research Progress and Challenges)
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Review

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30 pages, 6292 KiB  
Review
Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice
by Álan Gomes Pöppl, José Lucas Xavier Lopes, Taís Bock Nogueira, Denise Iparraguirre da Silva and Bruna dos Santos Machado
Animals 2024, 14(6), 890; https://doi.org/10.3390/ani14060890 - 14 Mar 2024
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Abstract
Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. This narrative review aims to provide relevant detailed information on (1) the canine estrus cycle and its impact on canine diabetes mellitus (CDM) etiology and management, (2) the [...] Read more.
Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. This narrative review aims to provide relevant detailed information on (1) the canine estrus cycle and its impact on canine diabetes mellitus (CDM) etiology and management, (2) the role of pyometra as a further cause of insulin resistance, and (3) useful individual therapeutic and preventive strategies. PRDM is recognized due to diestrus, exogenous progestogen exposure, pregnancy, and P4-production ovarian dysfunction. Pyometra represents additional inflammatory and septic negative influence on insulin sensitivity, and its diagnosis associated with CDM is therapeutically challenging. The estrus cycle’s hormone fluctuations seem to modulate peripheric insulin sensibility by influencing insulin receptor (IR) affinity and its binding capacity, as well as modulating tyrosine kinase activity. Pyometra was shown to negatively influence IR compensatory mechanisms to insulin resistance causing glucose intolerance. Spaying and pregnancy termination may cause diabetes remission in PRDM cases in a median time of 10 days (1–51). Pharmacological annulment of progesterone effects may benefit patients unable to undergo surgery; however, remission chances are virtually null. The ALIVE (Agreeing Language in Veterinary Endocrinology) project proposed new criteria for CDM diagnoses and subclinical diabetes recognition. These new concepts may increase the frequency of a PRDM diagnosis and, even more, its relevance. Spaying represents a preventive measure against pyometra and PRDM that should be individually assessed in light of its recognized benefits and harms. Full article
(This article belongs to the Special Issue Canine and Feline Endocrinology: Research Progress and Challenges)
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