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Animals
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Genetics and Genomics of Small Ruminants Prolificacy
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Genetics and Genomics of Small Ruminants Prolificacy

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1654

Special Issue Editor

Dr. Gabriel Anaya Calvo-Rubio

E-Mail Website
Guest Editor
MERAGEM Group, Department of Genetics, University of Córdoba, 14071 Córdoba, Spain
Interests: genomics; ruminant; improvement; prolificacy; production; wool; NGS; SNPs

Special Issue Information

Dear Colleagues,

Prolificacy in ruminants is an important trait in both meat and wool production. In meat production systems, multiple gestations are required, although they may result in lower offspring weight gain and/or an increase in mortality. On the other hand, an excess of prolificacy limits wool production due to the high expenditure of maternal resources on breeding rather than on fiber generation. Prolificacy depends on several environmental factors such as age, physiological status, or diet, among others; however, genetics have a fundamental impact. Knowledge of the genetic predisposition of herds regarding the size of the offspring could help in achieving the production objective: the management and feeding of the animals. Genetic and genomic methodologies allow the detection of new variants related to prolificacy that could be used as a criterion for selection in small ruminants.

The aim of this Special Issue is to present original papers and/or reviews on the genetics and genomics of small ruminant prolificacy focused on the search for genes that could be used as selection tools or focused on the improvement of prolificacy using classical selection with the use of new genetic evaluation methodologies. Other topics regarding the economic, health or production impacts of prolificacy will also be considered.

Dr. Gabriel Anaya Calvo-Rubio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prolificacy
  • ruminants
  • gene
  • genomic
  • selection
  • improvement

Published Papers (2 papers)

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Research

11 pages, 1813 KiB  
Article
Screening of Litter-Size-Associated SNPs in NOX4, PDE11A and GHR Genes of Sheep
by Jiajun Li, Yiming Gong, Xiangyu Wang, Xiaoyun He, Xiaolong He, Mingxing Chu and Ran Di
Animals 2024, 14(5), 767; https://doi.org/10.3390/ani14050767 - 29 Feb 2024
Viewed by 656
Abstract
In previous studies, NOX4, PDE11A and GHR genes have been screened as important candidate genes for litter size in sheep by using the GWAS method; however, neither their effects on litter size nor the loci associated with litter size have been identified. [...] Read more.
In previous studies, NOX4, PDE11A and GHR genes have been screened as important candidate genes for litter size in sheep by using the GWAS method; however, neither their effects on litter size nor the loci associated with litter size have been identified. In this study, three candidate loci (c.1057-4C > T in NOX4, c.1983C > T in PDE11A and c.1618C > T in GHR) were first screened based on our previous resequencing data of 10 sheep breeds. After the three loci were genotyped using Sequenom MassARRAY technology, we carried out population genetics analysis on the three loci and performed association analysis between the polymorphism of the three loci and the litter size of sheep. The results of population genetics analysis suggested that c.1057-4C > T in NOX4 and c.1983C > T in PDE11A may be subject to natural or artificial selection. The results of association analysis indicated that litter size was significantly associated with c.1057-4C > T in NOX4 and c.1983C > T in PDE11A (p < 0.05) in Small Tail Han sheep, and there was no significant interaction effect between the two loci on the litter size. In summary, c.1057-4C > T in NOX4 and c.1983 C > T in PDE11A can be considered candidate molecular markers for improving litter size in sheep. Full article
(This article belongs to the Special Issue Genetics and Genomics of Small Ruminants Prolificacy)
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0 pages, 1236 KiB  
Article
Association Analyses between Single Nucleotide Polymorphisms in ZFAT, FBN1, FAM184B Genes and Litter Size of Xinggao Mutton Sheep
by Yiming Gong, Qiuju Chen, Xiaolong He, Xiangyu Wang, Xiaoyun He, Yunfei Wang, Zhangyuan Pan, Mingxing Chu and Ran Di
Animals 2023, 13(23), 3639; https://doi.org/10.3390/ani13233639 - 24 Nov 2023
Viewed by 748
Abstract
Previous studies have screened key candidate genes for litter size in sheep, including fibrillin-1 (FBN1), family with sequence similarity 184 member B (FAM184B) and zinc finger and AT-hook domain containing (ZFAT). Therefore, it is necessary to verify [...] Read more.
Previous studies have screened key candidate genes for litter size in sheep, including fibrillin-1 (FBN1), family with sequence similarity 184 member B (FAM184B) and zinc finger and AT-hook domain containing (ZFAT). Therefore, it is necessary to verify these genes in the Xinggao mutton sheep population and determine the associated loci for litter size. In this study, three loci (FBN1 g.160338382 T > C, FAM184B g.398531673 C > T and ZFAT g.20150315 C > T) were firstly screened based on the population differentiation coefficient between the polytocous and monotocous sheep groups. Then, population genetic analysis and association analysis were performed on these loci. The results revealed that the g.160338382 T > C in FBN1 was significantly associated with the litter size of sheep. Moreover, there was no significant interaction effect between the g.160338382 T > C locus and FecB on litter size. Notably, g.160338382 T > C is adjacent to the anterior border of exon 58 and belongs to a splice polypyrimidine tract variant, which may lead to alternative splicing and ultimately cause changes in the structure and function of the protein. In summary, our results provided a potentially effective genetic marker for improving the litter size of sheep. Full article
(This article belongs to the Special Issue Genetics and Genomics of Small Ruminants Prolificacy)
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