Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging
Abstract
:1. Introduction
2. Materials and Methods
2.1. Discovery Dataset
2.2. Data Acquisition
2.3. fMRI Data Preprocessing
2.4. Vascular Evaluation in Renal fMRI
2.5. Stepwise Connectivity Analysis
2.6. Converged Rate of SFC Pattern
2.7. Association and Mediation Analysis
2.8. Reproducibility Analysis
3. Results
3.1. Bottom-Original SFC Patterns in Each Group
3.2. Top-Original SFC Patterns in Each Group
3.3. Altered SFC Pattern in Aging
3.4. Accelerated SFC Converged Rate in Older Adults
3.5. Interactive Relationship among SFC, Microvascular Features, and Behavioral Performance
3.6. Relationship between Altered SFC and Molecular Architecture
3.7. Replication RESULTS
4. Discussion
4.1. Altered Hierarchical Connectivity with Aging in the PSN and DMN
4.2. Altered Hierarchical Converged Rate and Trajectory with Aging
4.3. Relationship among SFC, Microvascular Features, and Behavioral Performance
4.4. Limitation
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Li, H.; Shi, H.; Jiang, S.; Hou, C.; Wu, H.; Yao, G.; Yao, D.; Luo, C. Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging. Bioengineering 2023, 10, 1166. https://doi.org/10.3390/bioengineering10101166
Li H, Shi H, Jiang S, Hou C, Wu H, Yao G, Yao D, Luo C. Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging. Bioengineering. 2023; 10(10):1166. https://doi.org/10.3390/bioengineering10101166
Chicago/Turabian StyleLi, Hechun, Hongru Shi, Sisi Jiang, Changyue Hou, Hanxi Wu, Gang Yao, Dezhong Yao, and Cheng Luo. 2023. "Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging" Bioengineering 10, no. 10: 1166. https://doi.org/10.3390/bioengineering10101166