Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. SD-OCT Procedure
2.3. Treatment Recommendations
2.4. Data Collection
2.5. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Subgroups | Total | ||
---|---|---|---|
NF1 | Non-NF1 | ||
Number of Patients | 4 | 9 | 13 |
Females | 4 | 4 | 8 (62%) |
Males | - | 5 | 5 (38%) |
Histology | 4 | 9 | 13 |
Pilomyxoid astrocytoma | - | 3 | 3 (23%) |
Pilocytic astrocytoma | - | 4 | 4 (31%) |
NA * | 4 | 2 | 6 (46%) |
Modified Dodge Classification | |||
2 bL | 2 | - | 2 (15%) |
4 bL | - | 1 | 1 (8%) |
H+ | 2 | 8 | 10 (77%) |
Events | - | 7 | 7 |
Progression | - | 7 | 7 |
Second neoplasm | - | - | - |
Deaths | - | 1 | 1 |
Tumour | - | 1 | 1 |
Other causes | - | - | - |
Variables | pRNFL (µm) Basal Median (IQR) | pRNFL (µm) First Follow-Up Median (IQR) | pRNFL (µm) Last Follow-Up Median (IQR) | p (Last Follow-Up Basal) | p (First Follow-Up Basal) |
---|---|---|---|---|---|
Progression Disease (PD) | 80.5 (20) | 66 (31) | 63.5 (17) | 0.0625 | 0.0625 |
Stable Disease (SD) | 103.5 (66.5) | 95 (42) | 98 (42.5) | 0.1250 | 0.1250 |
Partial Response (PR) | 104 (32.5) | 96.5 (30.5) | 95.5 (29) | 0.1250 | 0.1250 |
Total | 81.5 (31.5) | 73 (33) | 72 (38.5) | 0.0017 | 0.0017 |
OCT3-OCT1 | OCT2-OCT1 | |||||
---|---|---|---|---|---|---|
N | OR Difference > 10% (l.c. 95%) | N | OR Difference > 10% (l.c. 95%) | |||
Variable | >10% | <=10% | >10% | <=10% | ||
SD | 1 | 2 | 1.0 | 1 | 2 | 1.0 |
PD | 6 | 1 | 12.0 (0.5–294.6) | 5 | 2 | 5.0 (0.3–91.5) |
PR | 0 | 3 | 1.5−7 (not estimable) | 0 | 3 | 4.2−8 (not estimable) |
Tot | 7 | 6 | 6 | 7 |
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Pavone, R.; Fonte, C.; Sardi, I.; Caputo, R.; Marziali, E.; Mazzeo, F.; Secci, J.; Bergamini, A.; De Masi, S.; Leo, M.C.; et al. Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study. Children 2022, 9, 1307. https://doi.org/10.3390/children9091307
Pavone R, Fonte C, Sardi I, Caputo R, Marziali E, Mazzeo F, Secci J, Bergamini A, De Masi S, Leo MC, et al. Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study. Children. 2022; 9(9):1307. https://doi.org/10.3390/children9091307
Chicago/Turabian StylePavone, Rossana, Carla Fonte, Iacopo Sardi, Roberto Caputo, Elisa Marziali, Fabio Mazzeo, Jacopo Secci, Alessia Bergamini, Salvatore De Masi, Maria Carmela Leo, and et al. 2022. "Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study" Children 9, no. 9: 1307. https://doi.org/10.3390/children9091307