Nanoparticles and Their Antibacterial Application in Endodontics
Abstract
:1. Introduction
2. Methodology
3. Mechanism of Action of Nanoparticles
Connections between Nanoparticle Activity and Their Physical and Chemical Characteristics
4. Nanoparticles in Endodontics
4.1. Chitosan
4.2. Silver Nanoparticles
4.3. Graphene
4.4. Poly (Lactic) Co-Glycolic Acid
4.5. Bioactive Glass Nanoparticles
4.6. Mesoporous Calcium Silicate
4.7. Hydroxyapatite Nanoparticles
4.8. Zirconia
4.9. Glucose Oxidase Magnetic Nanoparticles
4.10. Copper Nanoparticles
4.11. Zinc Oxide Nanoparticles
5. Discussion and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sr. No. | Nanoparticles | Application | References |
---|---|---|---|
1. | Graphene | Antimicrobial properties of graphene oxide nanoparticles against common pathogens like S. mutans | [4,5] |
2. | Chitosan | They have excellent antimicrobial, antifungal, and antiviral activity based on electrostatic interaction, which leads to cell membrane disruption | [6,18,63] |
3. | Combination of chitosan nanoparticles and ZnONPs | Good antimicrobial activity against E. faecalis | [64] |
4. | Poly (lactic) co-glycolic acid | Conjugated with photoactive drugs and used for the eradication of microorganisms from endodontic canals | [5] |
5. | Poly (vinyl alcohol) (PVA)-coated AgNPs | Efficacious against P. aeruginosa, C. albicans, and E. faecalis | [65,66] |
6. | Silver nanoparticles (AgNPs) | AgNPs were observed to have antimicrobial and antifungal activity efficient against E. faecalis | [67,68] |
7. | Zinc oxide nanoparticles (ZnONPs) | ZnONPs have the ability to remove the planktonic E. faecalis and are able to disrupt the biofilm matrix | [69] |
8. | Photoactivated rose Bengal-conjugated chitosan nanoparticles | Inactivate endotoxins, in the presence of tissue inhibitors and functionalized nanoparticles showed a 50–65% reduction in planktonic E. faecalis | [70] |
9. | Calcium hydroxide nanoparticles | These nanoparticles improve the depth of penetration, increase surface area contact with pathogens, have superior solubility, and have greater antimicrobial activity | [71,72] |
10. | Chitosan and poly(lactic-co-glycolic) acid (PLGA) | Act as potential intracanal antibiotic delivery agents and possess good antimicrobial effects over 2 weeks | [73] |
11. | Porous calcium silicate and bioactive glass nanoparticles | Calcium silicate compounds are bioactive, biocompatible, and osteogenic because of their internal porous structures as well as their potential to act as drug carriers | [50] |
12. | Propolis-loaded PLGA nanoparticles | Antimicrobial activity against E. faecalis, S. mutans, and C. albicans. One of the applications was when doxycycline-functionalized polymP-n active nanoparticles were found to occlude dentinal tubules and exert against E. faecalis | [74] |
13. | Mesoporous calcium silicate | Drug delivery, antibacterial efficiencies, injectability, apatite mineralization, and osteo-stimulation | [75] |
14. | Hydroxyapatite nanoparticles | HAp integrates inside the dental tubules and seals the opening, helping prevent exposure to nerves to obnoxious external stimuli; therefore, they are used for decreasing dentin hypersensitivity | [76] |
15. | Iron compound (FeOx) | Helps in antibiotics for the removal of endodontic biofilms | [77] |
16. | Zirconia | Successfully used in the field of dentistry due to its optical and metallic properties similar to those of a tooth, and it also has antimicrobial effects | [64] |
17. | TiO2 nanoparticles | Used as an effective antifungal for fluconazole-resistant strains | [78,79] |
18. | CuO nanoparticles | Nanoparticles are active against Gram-positive and Gram-negative bacteria; they can cross the bacterial cell membrane and damage vital enzymes of bacteria and also possess antifungal activity | [57,75] |
19. | GOx-modified MNPs (GMNPs) | GOx-modified MNPs (GMNPs) exhibit antimicrobial activity against E. faecalis and C. albicans The ability of GMNPs to destroy dense matrix biofilm suggests that they can be successfully utilized against bacterial/fungal endodontic infections | [80,81] |
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Capuano, N.; Amato, A.; Dell’Annunziata, F.; Giordano, F.; Folliero, V.; Di Spirito, F.; More, P.R.; De Filippis, A.; Martina, S.; Amato, M.; et al. Nanoparticles and Their Antibacterial Application in Endodontics. Antibiotics 2023, 12, 1690. https://doi.org/10.3390/antibiotics12121690
Capuano N, Amato A, Dell’Annunziata F, Giordano F, Folliero V, Di Spirito F, More PR, De Filippis A, Martina S, Amato M, et al. Nanoparticles and Their Antibacterial Application in Endodontics. Antibiotics. 2023; 12(12):1690. https://doi.org/10.3390/antibiotics12121690
Chicago/Turabian StyleCapuano, Nicoletta, Alessandra Amato, Federica Dell’Annunziata, Francesco Giordano, Veronica Folliero, Federica Di Spirito, Pragati Rajendra More, Anna De Filippis, Stefano Martina, Massimo Amato, and et al. 2023. "Nanoparticles and Their Antibacterial Application in Endodontics" Antibiotics 12, no. 12: 1690. https://doi.org/10.3390/antibiotics12121690