Next Article in Journal
Effect of a Berry Polyphenolic Fraction on Biofilm Formation, Adherence Properties and Gene Expression of Streptococcus mutans and Its Biocompatibility with Oral Epithelial Cells
Next Article in Special Issue
Anticapsular and Antifungal Activity of α-Cyperone
Previous Article in Journal
Antimicrobial Stewardship: Development and Pilot of an Organisational Peer-to-Peer Review Tool to Improve Service Provision in Line with National Guidance
Previous Article in Special Issue
A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antibiotics
Volume 10
Issue 1
10.3390/antibiotics10010045
Review Report
antibiotics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Riboswitches as Drug Targets for Antibiotics

Antibiotics 2021, 10(1), 45; https://doi.org/10.3390/antibiotics10010045
by Vipul Panchal * and Ruth Brenk *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Antibiotics 2021, 10(1), 45; https://doi.org/10.3390/antibiotics10010045
Submission received: 30 November 2020 / Revised: 21 December 2020 / Accepted: 29 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Novel Targets and Mechanisms in Antimicrobial Drug Discovery)

Round 1

Reviewer 1 Report

This paper reviewed riboswitches as drug targets for antibiotics by introducing the TPP, FMN, glmS, guanine and other riboswitch ligands as antibacterial targets.

There are some minor concerns:

  1. It will be good to summarize the difference, advantage, and disadvantage of these riboswitch ligands on antibiotic discovery.
  2. Line 49 “… gene expression (open reading frame (ORF), marked in green).” But in Figure 1. ORF is marked in yellow.
  3. Line 272 What is “MIC”?
  4. Line 281 What is “WG-1”?
  5. Line 307 “RNAse” is not the same as “Rnase” in Figure 4.
  6. Line 355 “4. Guanine riboswitch ligands” should be “5. Guanine riboswitch ligands”?
  7. Line 382 What is “PC1”?

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comment 1: There are several mechanism by which bacteria develops antibiotic resistance. These mechanisms need to be discussed as well. 

Comment 2: Consequently, a need for a new generation ..... recognized Describe in details. What are the new generation of antibiotics??

Comment 3: "Riboswitches as drug targets for antibiotics" Why only antibiotics, it may be any other small molecule as well.

Comment 4: A discussion on the use of modern drug discovery approaches toward the design of riboswitch drug will be a valuable addition.

Comment 5:Table 1 needs revision as content from row is missing.

Comment 6: Most of the abbreviations are not explained when they are mentioned for the first time.

Author Response

Please see the attachmen

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The authors have addressed all the points.

Back to TopTop