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Pathogens
Volume 12
Issue 1
10.3390/pathogens12010145
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Review
Peer-Review Record

Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis?

Pathogens 2023, 12(1), 145; https://doi.org/10.3390/pathogens12010145
by Dorota Chrobak-Chmiel 1,*, Anna Golke 1, Ewelina Kwiecień 1, Małgorzata J. Biegańska 1, Kourou Dembele 2, Małgorzata Dziekiewicz-Mrugasiewicz 3, Michał Czopowicz 4, Magdalena Kizerwetter-Świda 1 and Magdalena Rzewuska 1
Reviewer 1:
Jaeson Calla
Reviewer 2:
Richard Halliwell
Pathogens 2023, 12(1), 145; https://doi.org/10.3390/pathogens12010145
Submission received: 28 December 2022 / Revised: 10 January 2023 / Accepted: 13 January 2023 / Published: 15 January 2023
(This article belongs to the Special Issue Immune Response of the Host and Vaccine Development)

Round 1

Reviewer 1 Report

Dear Authors,

This review presents canine atopic dermatitis (CAD) in a very organized way and how various factors are involved, making your treatment very complex. The role of vitamin D3 is also described very clearly.

The manuscript is very well-presented and written.

Author Response

Dear Reviewer,

we appreciate your kind review.

Kind regards

The authors

Reviewer 2 Report

This is a nice review of the clinical signs and treatment of canine atopic dermatitis. There is also a nice review of the role of antimicrobial peptides. In terms of the title given to the paper, there is little about the use of Vitamin D and analogues in human atopic dermatitis, and there is only one published paper on its use in canine atopic dermatitis. 

Minor points are:

Line 37: The term eczema is not used to describe canine atopic dermatitis.

Line 48: Suggest "Skin barrier function is further impaired by inflammation.

Line 101 and onwards: The use of lokivetmab is added at the end of the discussion of available treatments, - more or less as an afterthought. I suggest that it is brought in earlier.

Line 142: Should be "microbiome".

Line 177: Suggest: In response to the breaching of the epidermal barrier.

Author Response

Dear Reviewer,

we appreciate your valuable comments. All your suggestions have been taken into account. According to the Editor's suggestions the title and the abstract have been also modified.

Point by point responses to the minor Reviewer comments:

Line 37: the therm eczema has been removed from the manuscript.

Line 48: the sentence in this line has been modified into: "Skin barrier function is further impaired by inflammation".

Line 101: According to the Reviewer suggestion Lokivetmab has been listed as a treatment option earlier in the manuscript (now it is line 105) at the beginning of the paragraph concerning the treatment of CAD.

Line 142: The word "microbiome" is now correctly written, it was just the typo.

Line 177: We have changed the sentence according to the Reviewers suggestion.

Kind regards

The Authors

Round 2

Reviewer 2 Report

The authors have made the changes recommended. 

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