The Impact of RNA Interference in Tick Research
Round 1
Reviewer 1 Report
Dear authors,
I enjoyed reading your manuscript which may be ready for publication after addressing few minor corrections/comments highlighted directly in the document.
Comments for author File: 
Comments.pdf
Author Response
Reviewer 1
Dear authors,
I enjoyed reading your manuscript which may be ready for publication after addressing few minor corrections/comments highlighted directly in the document.
Response:
Thanks for your corrections, which were added to the revised manuscript.
Regarding Figure 1, it refers as disclosed in figure legend that these are model mechanisms inspired in the classic paper. In response to reviewer comments, “ISE6” and “organs” were added to the figure.
Figure 2 was revised as suggested by including “Citations of papers published before 2013?” Figure 2C legend was revised to include why papers before 2013 were included in the analysis, “Number of citations per paper published before 2013 (in the first decade after the classic paper by Aljamali et al. 2002 [18] was published) per research area”
Reviewer 2 Report
The authors provide a clear and concise overview of the history, methodology and impact of RNAi in tick research.
The article is nicely written with a clear chronological order and I found it interesting to read. The key references on the topic are included and the figures are clearly presented. Whilst I expect there are many more tick articles utilising RNAi than shown in Fig 2A, they were probably missed with the search terms used, however the graph as it is does show the increase and continued use of RNAi in tick research which is the main point.
This paper is a nice addition to the special issue on Classic Papers in Tick Research, and I consider it acceptable for publication in its current form.
Author Response
Reviewer 2
The authors provide a clear and concise overview of the history, methodology and impact of RNAi in tick research.
The article is nicely written with a clear chronological order and I found it interesting to read. The key references on the topic are included and the figures are clearly presented. Whilst I expect there are many more tick articles utilising RNAi than shown in Fig 2A, they were probably missed with the search terms used, however the graph as it is does show the increase and continued use of RNAi in tick research which is the main point.
This paper is a nice addition to the special issue on Classic Papers in Tick Research, and I consider it acceptable for publication in its current form.
Response: Thanks for your comments.
