Next Article in Journal
Regulation of the Actin Cytoskeleton-Linked Ca2+ Signaling by Intracellular pH in Fertilized Eggs of Sea Urchin
Next Article in Special Issue
Calreticulin and the Heart
Previous Article in Journal
Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
Previous Article in Special Issue
Mcl-1 Differentially Regulates Autophagy in Response to Changes in Energy Status and Mitochondrial Damage
Peer-Review Record

Circadian Governance of Cardiac Growth

Cells 2022, 11(9), 1494;
by Mary N. Latimer and Martin E. Young *
Reviewer 1:
Reviewer 2:
Cells 2022, 11(9), 1494;
Submission received: 19 April 2022 / Accepted: 26 April 2022 / Published: 29 April 2022
(This article belongs to the Special Issue Cardiac Growth Control and Heart Cell Death)

Round 1

Reviewer 1 Report

This is a very interesting review, well written, and derives significant clinical interest. The figures summarize the ideas nicely and allow the reader excellent "take home" messages. Background pioneering work is combined with contemporary areas of research, and are intermixed with clinical translation. Work of the authors is interwoven nicely with that of others in the field. A pleasure to read.

Reviewer 2 Report

This manuscript gives a comprehensive review on circadian phenomena in protein synthesis and growth in the heart. Evidence for why cardiac protein synthesis and growth peak at the awake-to-sleep transition are documented. It was proposed that the cardiomyocyte circadian clock regulates time-of-day-dependent rhythms in cardiac growth through both intrinsic and extrinsic timekeeping mechanisms. In addition, the authors provided opinion on the potential translational implications of circadian governance of cardiac growth. This manuscript is well-organized and clearly written and I recommend it to be accepted.

Back to TopTop