Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis of Polystyrene (PS) Sphere Template
2.3. Synthesis of Hollow Mesoporous Silica Microspheres (HMS)
2.4. Synthesis of N-(3,4-dihydroxyphenethyl) Methacrylamide (DMA)
2.5. Preparation of the KH570-Modified Silica Particle
2.6. Synthesis of HMS Nanoparticles Coated with Sensitive Polymer Shell
2.7. Characterization
2.8. DOX loading capacity and controlled release behaviors in Vito
3. Results
3.1. Optimizing the synthesis of HMS
3.2. Preparation of HMS@P(NIPAM-co-DMA)
3.3. DOX Loading and Controlled Release in Vitro
3.4. In Vitro Cytotoxicity Assay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Sample | Weight Loss < 250 °C [%] | Weight Loss at 250~800 °C [%] | Residue Weight [%] | Grafting Yield [%] |
---|---|---|---|---|
HMS | 2.5 | 4.1 | 93.4 | - |
HMS@KH570 | 2.0 | 16.2 | 81.8 | 14.8 |
HMS@P(NIPAM-co-DMA) | 3.9 | 26.4 | 69.7 | 14.6 |
Sample | Drug loading 1 [mg] | Loading capacity 1 (LC) [%] | Mass percentage 1 [%] | Entrapment efficiency 1 (EE) [%] | Mass percentage 2 [%] |
---|---|---|---|---|---|
HMS | 4.70 | 9.4 | 8.5 | 94.0 | 8.1 |
HMS@P(NIPAM-co-DMA-Fe3+) | 4.73 | 9.5 | 8.6 | 94.6 | 8.0 |
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Peng, W.; Zhang, Z.; Rong, M.; Zhang, M. Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex. Polymers 2019, 11, 1832. https://doi.org/10.3390/polym11111832
Peng W, Zhang Z, Rong M, Zhang M. Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex. Polymers. 2019; 11(11):1832. https://doi.org/10.3390/polym11111832
Chicago/Turabian StylePeng, Weili, Zeping Zhang, Minzhi Rong, and Mingqiu Zhang. 2019. "Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex" Polymers 11, no. 11: 1832. https://doi.org/10.3390/polym11111832