Measurement and Correlation of the Solubility of Florfenicol in Four Binary Solvent Mixtures from T = (278.15 to 318.15) K

Round 1

Reviewer 1 Report

Introduction:

Page 1: Please add information regarding water solubility of the drug.

Page 2 Line 49: Authors should add more background information about correlation of solubility data to models, its importance, purpose, and applications.

Methods:

Page 2 Line 78: How authors found that 12 hours was enough to achieve solid-liquid equilibrium?

Results:

Page 4 Line 155: As Reference 9 has reported, polymorph transformation and crystallization of other polymorph occurs during melting of the drug. Crystallization usually is an exothermic event. Therefore, calculated enthalpy of fusion may be related to melting and crystallization events. This possible error in calculating the enthalpy may affect obtained results.

Page 14: I think there is an error at Figure 5. This figure is similar to Figure 6.

Discussion and Conclusion:     

Authors have only reported their results. I think they need to relate their results to previous literature to suggest broad implications. Furthermore, it would be better to state the significance or application of the findings and suggest directions for future research.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This work by L. Zhou et al. describes “Measurement and Correlation of the Solubility of Florfenicol in Four Binary Solvent Mixtures from T = (278.15 to 318.15) K”. This is an interesting paper which is doubtlessly suitable for publication in “Crystals” in the special Issue, “Crystallization Process and Simulation Calculation”. The results are well supported by experimental facts and I recommend acceptance. However, Tables 1 to 4 should be placed as Supplementary Information.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf