A Beginner’s Guide to Thermodynamic Modelling of [FeFe] Hydrogenase
Round 1
Reviewer 1 Report
see the attached document.
Comments for author File: 
Comments.pdf
Author Response
Please see attached.
Author Response File: Author Response.pdf
Reviewer 2 Report
This work by Birrell and co-workers gave a nice introduction on how the pure mathematical models for the thermodynamics in [FeFe] hydrogenase can be constructed from simple to complicated situations. This work is definitely based upon Birrell's prior research work on the [FeFe] hydrogenase during the past few years.
This work nicely summarizes the thermodynamics models for [FeFe] hydrogenase constructed in their previous studies and gives the very detailed derivation processes. However, this also becomes the major limitation of this work in terms of novelty and significance.
In order to further strengthen the significance of this work, it would be useful to demonstrate to the readers how the constructed math models are employed in practice maybe by referring to their previous studies. In this way, interested readers can have a better feeling on how to use these models.
Author Response
Please see attached.
Author Response File: 
Author Response.docx
Round 2
Reviewer 2 Report
The authors have adopted the reviewers' suggestions and managed to convert the manuscript into a review article. I recommend this article to be published without further modifications.
