Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid
, Min-Koo Choi 2,* and Im-Sook Song 1,5,*
Round 1
Reviewer 1 Report
In this study, the plasma concentrations of the parent rosmarinic acid and conjugated rosmarinic 57 acid were about 20 nM and 1200 nM, respectively, at 1 h after oral intake of the Perilla frutescens 58 extract
Obs: "In this work" the conjugate does not appear.The wording needs to be changed.
Obs, Which is rosmarinic acid solubility? Partition coefficient ? The main problem of the paper is that,
going to very low concentrations,
the estimates regarding
the elimination constant are no longer plausible.
Elimination is no longer bi-exponential but tri-exponential. The extrapolated areas
do not differ much from those up to 6 hours.
As a result, it would be sufficient to do the analysis
only for up to 6 hours.
Author Response
please see the attached file
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The whole work is interesting.
It lacks some minor aspects such as :
1/-the evaluation of the matrix effect in analytical methods and details of the performance of the assay;
2/-the criteria for the choice of models describing their data;
3/-the graphical detail on residuals or prediction deviations when the model is selected.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
In this form, the work seems to me correct and complete