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Brief Report
Peer-Review Record

Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein Variants in a Population of Black PLWH Vaccinated with ChAdOx1 nCoV-19

Viruses 2023, 15(2), 448; https://doi.org/10.3390/v15020448
by Muneerah Smith 1, Gaurav Kwatra 2,3,4, Alane Izu 2, Andrew Nel 1, Clare Cutland 4, Khatja Ahmed 5, Vicky Baillie 2, Shaun Barnabas 6, Qasim Bhorat 7, Carmen Briner 8, Erica Lazarus 8, Keertan Dheda 9,10, Lee Fairlie 11, Anthonet Koen 2, Shabir Madhi 2,4 and Jonathan M. Blackburn 1,12,13,*
Reviewer 1:
Reviewer 2:
Reviewer 3: Anonymous
Viruses 2023, 15(2), 448; https://doi.org/10.3390/v15020448
Submission received: 25 December 2022 / Revised: 25 January 2023 / Accepted: 4 February 2023 / Published: 6 February 2023
(This article belongs to the Section SARS-CoV-2 and COVID-19)

Round 1

Reviewer 1 Report

Dear all,

 

your manuscript is well written , an interesting subject but I consider it can be improved in English language a little

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

A more extended "discussions" session would be beneficial as well as a paragraph of conclusions.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 3 Report

The authors have presented interesting results in a study looking at longitidinal IgA and IgG responses and temporal patterns in face of encountering full-length SARS-CoV-2 spike protein variantin in a population on PLWH (immunocompromised cases) already vaccinated with ChAdOx1 nCoV-19. 

While the study is designed well and is on an important and timely topic, the authors need to improve the paper by addresing the following issues:

 

1. The figures must be in colosr and all in formation should be in the plots (time scales, ....). Current figures are not informative.

2. Authors need to highlight the novel findings they have reached in more details.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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