Next Article in Journal
A Novel Terrestrial Rabies Virus Lineage Occurring in South America: Origin, Diversification, and Evidence of Contact between Wild and Domestic Cycles
Next Article in Special Issue
A Novel High-Throughput Nanopore-Sequencing-Based Strategy for Rapid and Automated S-Protein Typing of SARS-CoV-2 Variants
Previous Article in Journal / Special Issue
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 13
Issue 12
10.3390/v13122483
Review Report
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Antibody-Dependent Enhancement of SARS-CoV-2 Infection of Human Immune Cells: In Vitro Assessment Provides Insight in COVID-19 Pathogenesis

Viruses 2021, 13(12), 2483; https://doi.org/10.3390/v13122483
by Xu-Rui Shen 1,2,†, Qian Li 1,2,†, Hui-Ling Li 1,†, Xi Wang 1,2, Qi Wang 1,2, Xiao-Shuang Zheng 1,2, Rong Geng 1,2, Yu-Lan Zhang 1, Bei Li 1, Ren-Di Jiang 1, Mei-Qin Liu 1, Yan Zhu 1, Wei Zhang 1, Xing-Lou Yang 1, Ke Peng 1,* and Peng Zhou 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Viruses 2021, 13(12), 2483; https://doi.org/10.3390/v13122483
Submission received: 14 November 2021 / Revised: 7 December 2021 / Accepted: 8 December 2021 / Published: 11 December 2021
(This article belongs to the Collection SARS-CoV-2 and COVID-19)

Round 1

Reviewer 1 Report

Thank tou for interesting work.

The test on human pulmonary cell will be more intetesting, but your researche are new and also very interesting.

More tests shuold be performed .

Author Response

Thanks for your advice. We have added a short part to the introduction. We also realized more tests should be performed to make the work better, for example animal work, which is in our future plan. As the current study, we feel the conclusion is clear for the in vitro study.

Reviewer 2 Report

The authors aimed to test SARS-CoV-2 induced antibody-dependent enhancement (ADE) in vitro using convalescent COVID-19 patient serum samples in a list of FcγR-expression leukocytes, in the view to contributed to the understanding of the pathogenesis of SARS-COV-2 in the context of viral treatment and control.

The study covers some issues that have been overlooked in other similar topics. The structure of the manuscript appears adequate and well divided in the sections. The methodology is well described with enough experimental data and results to support the work.

Conclusion Section: This paragraph is missing. Please add it.

Author Response

Thanks for pointing out.  A paragraph for conclusion has been added to the discussion part. 

Back to TopTop